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Literature summary extracted from

  • Duffell, K.M.; Hudson, S.A.; McLean, K.J.; Munro, A.W.; Abell, C.; Matak-Vinkovic, D.
    Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions (2013), Anal. Chem., 85, 5707-5714.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.70 44962
-
 2 * 44962, calculated from amino acid sequence, CYP121 is a predominantly dimeric protein, with a minor monomeric form present Mycobacterium tuberculosis
1.14.19.70 89940
-
 nanoelectrospray ionization mass spectrometry Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis H37Rv
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.70 Mycobacterium tuberculosis P9WPP7
-
-
1.14.19.70 Mycobacterium tuberculosis H37Rv P9WPP7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis H37Rv mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.70 homodimer 2 * 44962, calculated from amino acid sequence, CYP121 is a predominantly dimeric protein, with a minor monomeric form present Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.14.19.70 CYP121
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.14.19.70 physiological function the enzyme is essential for bacterial viability Mycobacterium tuberculosis