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Literature summary extracted from

  • Zhang, R.Y.; Qin, Y.; Lv, X.Q.; Wang, P.; Xu, T.Y.; Zhang, L.; Miao, C.Y.
    A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase (2011), Anal. Biochem., 412, 18-25.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.12 expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 (4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
-
 Mus musculus
2.4.2.12 (4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)
-
 Mus musculus
2.4.2.12 FK-866 i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide Mus musculus
2.4.2.12 gallotanine i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate) Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.12 immobilized metal ion affinity chromatography Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phosphoribosyl 1-diphosphate
-
 Mus musculus nicotinamide mononucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 nicotinamide phosphoribosyltransferase
-
 Mus musculus
2.4.2.12 PBEF
-
 Mus musculus
2.4.2.12 Visfatin
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.12 0.0000009
-
 i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide, pH 7.5, 37°C Mus musculus FK-866
2.4.2.12 0.0013
-
 i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate), pH 7.5, 37°C Mus musculus gallotanine
2.4.2.12 0.0066
-
 pH 7.5, 37°C Mus musculus (4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
2.4.2.12 0.0175
-
 pH 7.5, 37°C Mus musculus (4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)