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Literature summary extracted from

  • Nishimura, K.; Lee, S.B.; Park, J.H.; Park, M.H.
    Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development (2012), Amino Acids, 42, 703-710.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.46 additional information construction of heterozygous or homozygous knockout mice via stem cell lines, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Mus musculus
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Mus musculus C57/BL6J
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Mus musculus
-
 gene Dhps
-
2.5.1.46 Mus musculus C57/BL6J
-
 gene Dhps
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 blastocyst
-
 Mus musculus
-
2.5.1.46 ES cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Mus musculus [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Mus musculus C57/BL6J [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.46 DHPS
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.5.1.46 malfunction severe effects of knockout of Eif5a gene or Dhps gene in mice in cell lines RRE174 with Eif5a disruption and RRM039 with Dhps disruption, Eif5a heterozygous knockout mice and Dhps heterozygous knockout mice are viable and fertile, but, homozygous Eif5a1gt/gt embryos and Dhpsgt/gt embryos die early in embryonic development. Upon transfer to in vitro culture, homozygous Eif5agt/gt or Dhpsgt/gt blastocysts at E3.5 show growth defects when compared to heterozygous or wild-type blastocysts Mus musculus
2.5.1.46 physiological function hypusine is formed posttranslationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase, DHPS, and subsequent hydroxylation by deoxyhypusine hydroxylase, DOHH. Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development, overview Mus musculus