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Literature summary extracted from

  • Hyvoenen, M.T.; Keinaenen, T.A.; Khomutov, M.; Simonian, A.; Vepsaelaeinen, J.; Park, J.H.; Khomutov, A.R.; Alhonen, L.; Park, M.H.
    Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A (2012), Amino Acids, 42, 685-695.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 2-methylspermidine
-
 Homo sapiens
2.5.1.46 3-methylspermidine
-
 Homo sapiens
2.5.1.46 4-methylspermidine
-
 Homo sapiens
2.5.1.46 N-(3-aminopropyl)-N'-methylbutane-1,4-diamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 additional information Homo sapiens as racemic mixtures, only 2-MeSpd and 3-MeSpd support long-term growth (9-18 days) of spermidine-depleted DU-145 cells, whereas gamma-MeSpd and omega-MeSpd do not ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 2-methylspermidine Homo sapiens
-
 ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 3-methylspermidine Homo sapiens
-
 ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Homo sapiens
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 DU-145 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 additional information as racemic mixtures, only 2-MeSpd and 3-MeSpd support long-term growth (9-18 days) of spermidine-depleted DU-145 cells, whereas gamma-MeSpd and omega-MeSpd do not Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 2-methylspermidine
-
 Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 2-methylspermidine the S-enantiomer of 2-MeSpd, which supports long-term growth, is a good substrate for DHS in vitro, whereas the R isomer is not Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 3-methylspermidine
-
 Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + 4-methylspermidine
-
 Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.5.1.46 DHS
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.46 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.46 9.5
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.5.1.46 physiological function hypusine modification is an irreversible protein modification and naturally occurring eIF5A exists predominantly as the hypusinated form. Deoxyhypusine synthase catalyzes the transfer of the aminobutyl moiety from spermidine to a specific lysine of the eIF5A precursor to form the deoxyhypusine [N?-(4-aminobutyl)lysine] intermediate. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase Homo sapiens