Literature summary extracted from

Shi, C.; Welsh, P.A.; Sass-Kuhn, S.; Wang, X.; McCloskey, D.E.; Pegg, A.E.; Feith, D.J.
Characterization of transgenic mice with overexpression of spermidine synthase (2012), Amino Acids, 42, 495-505.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.5.1.16	gene spdS, overexpression in transgenic C57BL/6J mice	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.5.1.16	additional information	generation of transgenic mice overexpressing the human SpdS, the mice are viable and fertile and tissue SpdS activity is increased up to 9fold. This increased SpdS activity does not result in a dramatic elevation of spermidine or spermine levels but leads to a 1.5 to 2fold reduction in tissue spermine:spermidine ratio in heart, muscle and liver tissues with the highest levels of SpdS activity	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.16	S-adenosylmethioninamine + putrescine	Homo sapiens	-	S-methyl-5'-thioadenosine + spermidine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.16	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.16	S-adenosylmethioninamine + putrescine	-	Homo sapiens	S-methyl-5'-thioadenosine + spermidine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.5.1.16	SPDS	-	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.5.1.16	6.8	7.2	assay at	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.5.1.16	physiological function	spermidine synthhase is responsible for spermdine synthesis from putrescine, the polyamines putrescine, spermidine and spermine are cationic molecules that are found in all eukaryotic cells and are clearly essential to growth and development	Homo sapiens

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Release 2023.1 (January 2023)