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Literature summary extracted from

  • Errico, A.; Deshmukh, K.; Tanaka, Y.; Pozniakovsky, A.; Hunt, T.
    Identification of substrates for cyclin dependent kinases (2010), Adv. Enzyme Regul., 50, 375-399.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 cyclin A activates Cdk2 Xenopus laevis
2.7.11.22 cyclin B activates CDK1 Xenopus laevis
2.7.11.22 cyclin E activates Cdk2 Xenopus laevis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Xenopus laevis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + acidic alpha-syntrophin protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + acidic alpha-syntrophin phosphoprotein
-
 ?
2.7.11.22 ATP + ADP-ribosylation factor GTPase activating protein 3 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
-
 ?
2.7.11.22 ATP + AE binding protein 2 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + AE binding protein 2 phosphoprotein
-
 ?
2.7.11.22 ATP + APEX nuclease protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + APEX nuclease phosphoprotein
-
 ?
2.7.11.22 ATP + ARAF serine/threonine protein kinase protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + ARAF serine/threonine protein kinase phosphoprotein
-
 ?
2.7.11.22 ATP + ATRIP protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + ATRIP phosphoprotein
-
 ?
2.7.11.22 ATP + cAMP responsive element binding protein 3-like 2 protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
-
 ?
2.7.11.22 ATP + CCAAT/enhancer binding protein gamma protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + CCAAT/enhancer binding protein gamma phosphoprotein
-
 ?
2.7.11.22 ATP + coiled-coil domain protein 52 protein substrate of cyclin E/CDK2, not of cyclinA/CDK2 Xenopus laevis ADP + coiled-coil domain protein 52 phosphoprotein
-
 ?
2.7.11.22 ATP + CPEB-associated factor Maskin protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + CPEB-associated factor Maskin phosphoprotein
-
 ?
2.7.11.22 ATP + diacylglycerol kinase epsilon protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + diacylglycerol kinase epsilon phosphoprotein
-
 ?
2.7.11.22 ATP + diphthamide biosynthesis protein 2 isoform a protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
-
 ?
2.7.11.22 ATP + distal-less homeobox 1 isoform 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + distal-less homeobox 1 isoform 1 phosphoprotein
-
 ?
2.7.11.22 ATP + Erp1/emi2 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + Erp1/emi2 phosphoprotein
-
 ?
2.7.11.22 ATP + establishment of cohesion-1 homologue 2 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + establishment of cohesion-1 homologue 2 phosphoprotein
-
 ?
2.7.11.22 ATP + ETS variant gene-1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + ETS variant gene-1 phosphoprotein
-
 ?
2.7.11.22 ATP + Fizzy1 protein substrate of cyclin E/CDK2, not of cyclinA/CDK2 Xenopus laevis ADP + Fizzy1 phosphoprotein
-
 ?
2.7.11.22 ATP + glycogenin protein substrate of cyclin B/CDK1, not of cyclinA/CDK2 Xenopus laevis ADP + glycogenin phosphoprotein
-
 ?
2.7.11.22 ATP + granulin isoform 1 precursor protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + granulin isoform 1 precursor phosphoprotein
-
 ?
2.7.11.22 ATP + heat shock transcription factor 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + heat shock transcription factor 1 phosphoprotein
-
 ?
2.7.11.22 ATP + Hermes protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + Hermes phosphoprotein
-
 ?
2.7.11.22 ATP + histone deacetylase 6 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + histone deacetylase 6 phosphoprotein
-
 ?
2.7.11.22 ATP + histone stem-loop binding protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + histone stem-loop binding phosphoprotein
-
 ?
2.7.11.22 ATP + Kunitz type serine protease inhibitor 2 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
-
 ?
2.7.11.22 ATP + lamina-associated protein 2-beta isoform protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + lamina-associated protein 2-beta isoform phosphoprotein
-
 ?
2.7.11.22 ATP + LOC222229 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + LOC222229 phosphoprotein
-
 ?
2.7.11.22 ATP + low density lipoprotein receptor adaptor protein 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
-
 ?
2.7.11.22 ATP + MAP/microtubule affinity regulating kinase 3 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
-
 ?
2.7.11.22 ATP + maternal embryonic leucine zipper kinase protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + maternal embryonic leucine zipper kinase phosphoprotein
-
 ?
2.7.11.22 ATP + MGC86234 protein i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + MGC86234 phosphoprotein
-
 ?
2.7.11.22 ATP + minor histocompatibility antigen HA-1 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + minor histocompatibility antigen HA-1 phosphoprotein
-
 ?
2.7.11.22 ATP + palmitoylated membrane protein 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + palmitoylated membrane protein 1 phosphoprotein
-
 ?
2.7.11.22 ATP + PASCIN protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + PASCIN phosphoprotein
-
 ?
2.7.11.22 ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
-
 ?
2.7.11.22 ATP + PIF1 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + PIF1 phosphoprotein
-
 ?
2.7.11.22 ATP + POM21 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + POM21 phosphoprotein
-
 ?
2.7.11.22 ATP + pre-B-cell leukemia transcription factor 1 protein substrate of cyclinA/CDK2, not of cyclin B/CDK1 Xenopus laevis ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
-
 ?
2.7.11.22 ATP + RNA polymerase 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + RNA polymerase 1 phosphoprotein
-
 ?
2.7.11.22 ATP + SEC14-like 1 isoform a protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + SEC14-like 1 isoform a phosphoprotein
-
 ?
2.7.11.22 ATP + semaphorin 6D protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + semaphorin 6D phosphoprotein
-
 ?
2.7.11.22 ATP + similar to bicaudal C homologue 1 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + similar to bicaudal C homologue 1 phosphoprotein
-
 ?
2.7.11.22 ATP + similar to peroxisomal biogenesis factor 5 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
-
 ?
2.7.11.22 ATP + similar to Trigger of mitotic entry 1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + similar to Trigger of mitotic entry 1 phosphoprotein
-
 ?
2.7.11.22 ATP + similar to Zinc finger protein 516 protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + similar to Zinc finger protein 516 phosphoprotein
-
 ?
2.7.11.22 ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
-
 ?
2.7.11.22 ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
-
 ?
2.7.11.22 ATP + striatin protein substrate of cyclin E/CDK2, not of cyclinA/CDK2 Xenopus laevis ADP + striatin phosphoprotein
-
 ?
2.7.11.22 ATP + TATA box-binding protein-associated factor 2F protein substrate of cyclin B/CDK1, not of cyclinA/CDK2 Xenopus laevis ADP + TATA box-binding protein-associated factor 2F phosphoprotein
-
 ?
2.7.11.22 ATP + telomeric repeat binding factor 2 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + telomeric repeat binding factor 2 phosphoprotein
-
 ?
2.7.11.22 ATP + Tipin protein substrate of cyclinA/CDK2 and cyclin E/CDK2 Xenopus laevis ADP + Tipin phosphoprotein
-
 ?
2.7.11.22 ATP + v-raf murine sarcoma viral oncogene homolog B1 protein substrate of cyclin B/CDK1 and cyclinA/CDK2 Xenopus laevis ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
-
 ?
2.7.11.22 ATP + Xenopus laevis protein associated with PRK1 protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
-
 ?
2.7.11.22 ATP + zinc finger protein 46 protein substrate of cyclinA/CDK2, not of cyclin E/CDK2 Xenopus laevis ADP + zinc finger protein 46 phosphoprotein
-
 ?
2.7.11.22 additional information identification 35 substrates from screening for cyclin B/CDK1, and investigation of the differential specificity of cyclin B/CDK1 versus cyclin A/CDK1 and cyclin A/CDK2. About half the substrates are equally well phosphorylated regardless of the cyclin or the CDK, computational analysis, overview Xenopus laevis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk1
-
 Xenopus laevis
2.7.11.22 CDK2
-
 Xenopus laevis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
 Xenopus laevis