EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.149 | PI5P4Kalpha is predominantly in the cytoplasm, principally cytosolic, when recombinantly expressed | Mammalia |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.149 | cytosol | recombinantly expressed PI5P4Kalpha | Mammalia | 5829 | - |
2.7.1.149 | membrane | PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus | Mammalia | 16020 | - |
2.7.1.149 | additional information | analysis of subcellular localization of native and recombinant isozyme PI5P4Kalpha, overview | Mammalia | - |
- |
2.7.1.149 | nucleus | PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus | Mammalia | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.149 | Mg2+ | required | Mammalia |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.149 | ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Mammalia | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.149 | Mammalia | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.149 | DT-40 cell | - |
Mammalia | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.149 | ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Mammalia | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.149 | phosphatidylinositol 5-phosphate 4-kinase | - |
Mammalia |
2.7.1.149 | PI5P4K | - |
Mammalia |
2.7.1.149 | PI5P4Kalpha | - |
Mammalia |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.149 | ATP | - |
Mammalia |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.149 | evolution | PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction | Mammalia |