Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gradinaru, D.; Minn, A.L.; Artur, Y.; Minn, A.; Heydel, J.M.
    Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes (2012), Toxicol. Lett., 213, 316-324.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 additional information significant inhibition of glucuronidation enzymatic activity in the presence of all the tested reactive oxygen species generators. Presence of higher concentrations of a reactive oxygen species generating xenobiotic compound, i.e. menadione to a concentration of 100 microM, has no inhibitory effect on glucuronidation activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 astrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 1-naphthol + UDP-alpha-D-glucuronate
-
 Rattus norvegicus 1-naphthyl O-glucuronide + UDP
-
 ?

General Information

EC Number General Information Comment Organism
2.4.1.17 physiological function oxidative stress induces significant deleterious changes in astrocyte morphology, decreases cell viability and inhibits catalytic function of UDP-glucuronosyltransferases as a result of protein oxidation. Alternatively, in the surviving impaired astrocytes, oxidative conditions induces a significant overactivity and overexpression of xenobiotic detoxification enzymes, as adaptive response. These effects are significantly prevented by the presence of melatonin, reflected further on the glucuronidation activity and transcriptional regulation of both UGT1A6 and UGT1A7. Both catalytic properties of UDP-glucuronosyltransferases and the expression of UGT1A6, UGT1A7, NQO1 and NADPH:cytochrome P450 reductase in rat astrocytes are greatly influenced by the pro-oxidative environment Rattus norvegicus