Literature summary extracted from

Berdichevsky, A.; Nedelcu, S.; Boulias, K.; Bishop, N.A.; Guarente, L.; Horvitz, H.R.
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1 (2010), Proc. Natl. Acad. Sci. USA, 107, 18927-18932.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.16	Caenorhabditis elegans	Q22100	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.16	KAT-1	-	Caenorhabditis elegans

General Information

EC Number	General Information	Comment	Organism
2.3.1.16	physiological function	loss-of-function mutations of the ketoacyl thiolase gene kat-1 result in an increased accumulation of the lipofuscin-like fluorescent aging pigment, shortened lifespan, early behavioral decline, and other abnormalities characteristic of premature aging. Isoform kat-1 is required for the extension of lifespan and enhanced thermotolerance mediated by extra copies of the deacetylase gene sir-2.1. kat-1 acts independently of other known pathways that affect longevity	Caenorhabditis elegans

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Release 2023.1 (January 2023)