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Literature summary extracted from

  • Anbazhagan, D.; Mansor, M.; Yan, G.O.; Md Yusof, M.Y.; Hassan, H.; Sekaran, S.D.
    Detection of quorum sensing signal molecules and identification of an autoinducer synthase gene among biofilm forming clinical isolates of Acinetobacter spp. (2012), PLoS ONE, 7, e36696.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.184 gene abaI, DNA and amino acid sequence determination and analysis in the different clinical isolates Acinetobacter sp.

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.184 additional information inactivation of abaI gene in the chromosome of the Acinetobacter spp. S117 by insertion disruption, using the middle along with the flanking chromosomal DNA cloned into pUC18-based suicide delivery vector from Escherichia coli K12 carrying the pUC18-abaI::Tc plasmid, introduction of the plasmid by conjugation Acinetobacter sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Acinetobacter sp.
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 additional information Acinetobacter sp. five of the clinical isolates produce N-decanoyl homoserine lactone and two isolates produce acyl-homoserine lactone with a chain length equal to C12 ?
-
 ?
2.3.1.184 N-decanoyl -[acyl-carrier protein] + S-adenosyl-L-methionine Acinetobacter sp.
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-decanoyl -L-homoserine lactone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.184 Acinetobacter sp.
-
 clinical isolates, gene abaI
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Acinetobacter sp. an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 additional information five of the clinical isolates produce N-decanoyl homoserine lactone and two isolates produce acyl-homoserine lactone with a chain length equal to C12 Acinetobacter sp. ?
-
 ?
2.3.1.184 N-decanoyl -[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Acinetobacter sp. [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-decanoyl -L-homoserine lactone
-
 ?

General Information

EC Number General Information Comment Organism
2.3.1.184 physiological function abaI encodes an enzyme that is involved in production of N-acyl-homoserine lactones as quorum sensing signal molecules. The signal molecules aid in biofilm formation which in turn confer various properties of pathogenicity to the clinical isolates including drug resistance. Quorum sensing is a regulatory mechanism which enables bacteria to make collective decisions with respect to the expression of a specific set of genes. These includes genes involved in biofilm formation and virulence Acinetobacter sp.