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Literature summary extracted from

  • Hosni-Ahmed, A.; Barnes, J.D.; Wan, J.; Jones, T.S.
    Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure (2011), PLoS ONE, 6, e29163.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.67 medicine low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells Mus musculus
2.1.1.67 medicine low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytoplasm
-
 Mus musculus 5737
-
2.1.1.67 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-
2.1.1.67 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 A-172 cell
-
 Homo sapiens
-
2.1.1.67 astrocyte primary cell Mus musculus
-
2.1.1.67 astroglial cell
-
 Mus musculus
-
2.1.1.67 T-98 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + thioguanine nucleotide
-
 Mus musculus S-adenosyl-L-homocysteine + methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + thioguanine nucleotide
-
 Homo sapiens S-adenosyl-L-homocysteine + methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + thioinosine monophosphate
-
 Mus musculus S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
 ?
2.1.1.67 S-adenosyl-L-methionine + thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine methyltransferase
-
 Mus musculus
2.1.1.67 thiopurine methyltransferase
-
 Homo sapiens
2.1.1.67 TPMT
-
 Mus musculus
2.1.1.67 TPMT
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.67 malfunction when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure Mus musculus
2.1.1.67 malfunction when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure Homo sapiens