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Literature summary extracted from

  • Thayil, S.M.; Morrison, N.; Schechter, N.; Rubin, H.; Karakousis, P.C.
    The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence (2011), PLoS ONE, 6, e28076.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.11 expressed in Escherichia coli Arctic Express (DE3) cells Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.11 36600
-
 x * 36600, SDS-PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.11 Mycobacterium tuberculosis P9WHV4
-
-
3.6.1.11 Mycobacterium tuberculosis CDC 1551 P9WHV4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.11
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.11 (phosphate)n + H2O
-
 Mycobacterium tuberculosis (phosphate)n-1 + phosphate
-
 ?
3.6.1.11 (phosphate)n + H2O
-
 Mycobacterium tuberculosis CDC 1551 (phosphate)n-1 + phosphate
-
 ?
3.6.1.11 additional information the enzyme does not cleave ppGpp Mycobacterium tuberculosis ?
-
 ?
3.6.1.11 additional information the enzyme does not cleave ppGpp Mycobacterium tuberculosis CDC 1551 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.11 ? x * 36600, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.6.1.11 MT0516
-
 Mycobacterium tuberculosis
3.6.1.11 PPX
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.6.1.11 malfunction deficiency of exopolyphosphatase results in decelerated growth during logarithmic-phase in axenic cultures, and tolerance to the cell wall-active drug isoniazid. The enzyme-deficient mutant shows a significant survival defect in activated human macrophages and reduced persistence in the lungs of guinea pigs Mycobacterium tuberculosis
3.6.1.11 physiological function exopolyphosphatase is required for long-term survival of Mycobacterium tuberculosis in necrotic lung lesion Mycobacterium tuberculosis