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Literature summary extracted from
- Redox regulation of insulin degradation by insulin-degrading enzyme (2011), PLoS ONE, 6, e18138.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.56 | glutathione | oxidized glutathione inhibits IDE through glutathionylation, which is reversible by dithiothreitol but not by ascorbic acid | Rattus norvegicus |  |
| 3.4.24.56 | S-nitrosoglutathione | inhibits IDE-mediated degradation of two IDE substrates, insulin and amyloid beta | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.56 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.56 | liver | - |
Rattus norvegicus | - |
| 3.4.24.56 | muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.56 | amyloid beta peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.56 | insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.56 | IDE | - |
Rattus norvegicus |
| 3.4.24.56 | Insulysin | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.56 | 37 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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