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Literature summary extracted from

  • Tran, N.Q.; Pham, X.H.; Tuteja, R.; Tuteja, N.
    Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin (2011), Plant Signal. Behav., 6, 327-329.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.4 actinomycin
-
 Pisum sativum
5.6.2.4 daunorubicin less efficient inhibition of DNA helicase activity, but no inhibition of ATPase activity Pisum sativum
5.6.2.4 doxorubicin less efficient inhibition of DNA helicase activity, but no inhibition of ATPase activity Pisum sativum
5.6.2.4 Nogalamycin
-
 Pisum sativum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.2.4 93000
-
 single subunit Pisum sativum
5.6.2.4 560000
-
 homohexamer Pisum sativum

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.4 Pisum sativum Q8H1A3
-
-

Subunits

EC Number Subunits Comment Organism
5.6.2.4 hexamer homohexamer, 6 * 93000 Pisum sativum

Synonyms

EC Number Synonyms Comment Organism
5.6.2.4 MCM6 DNA helicase
-
 Pisum sativum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.4 37
-
 assay at Pisum sativum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.4 8
-
 assay at Pisum sativum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.6.2.4 0.001
-
 Nogalamycin pH 8.0, 37°C, inhibition of DNA helicase activity Pisum sativum
5.6.2.4 0.01
-
 actinomycin pH 8.0, 37°C, inhibition of DNA helicase activity Pisum sativum
5.6.2.4 0.017
-
 Nogalamycin pH 8.0, 37°C, inhibition of ATPase activity Pisum sativum
5.6.2.4 0.1
-
 actinomycin pH 8.0, 37°C, inhibition of ATPase activity Pisum sativum