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Literature summary extracted from

  • Onrubia, M.; Moyano, E.; Bonfill, M.; Palazon, J.; Goossens, A.; Cusido, R.M.
    The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets (2011), Plant Sci., 181, 282-287.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.167 acetyl-CoA + 10-deacetylbaccatin III Taxus baccata
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CoA + baccatin III
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?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.167 Taxus baccata
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.167 aerial part
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Taxus baccata
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2.3.1.167 additional information higher content of 10-deacetylbaccatin III in the aerial part of the plantlets than in the roots Taxus baccata
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2.3.1.167 root
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Taxus baccata
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.167 acetyl-CoA + 10-deacetylbaccatin III
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Taxus baccata CoA + baccatin III
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.167 10-deacetylbaccatin III-10beta-O-acetyltransferase
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Taxus baccata
2.3.1.167 DBAT
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Taxus baccata

General Information

EC Number General Information Comment Organism
2.3.1.167 metabolism the relationship between taxane patterns and the expression of genes encoding the enzymes taxadiene synthase, 10-deacetylbaccatin III-10beta-O-acetyltransferase, baccatin III 13-O-(3-amino-3-phenylpropanoyl) transferase and 3'-N-debenzoyl-2'-deoxytaxol-N-benzoyltransferase, involved in early and late steps of the taxane pathway, overview. The most abundant taxane in the aerial parts is 10-deacetylbaccatin III, which increases as the plantlets grow, indicating a low conversion to baccatin III and taxol. In contrast, the levels of 10-deacetylbaccatin III in the roots remain lower than those of taxol. But in the aerial parts the expression of DBAT, which codes for the enzyme that converts 10-deacetylbaccatin III into baccatin III, does not increase with the age of plantlets, unlike that of the other three enzymes, suggesting that this gene controls a rate-limiting step in the taxane biosynthetic pathway Taxus baccata