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Literature summary extracted from

  • Raharjo, T.; Chang, W.; Choi, Y.; Peltenburg-Looman, A.; Verpoorte, R.
    Olivetol as product of a polyketide synthase in Cannabis sativa L (2004), Plant Sci., 166, 381-385.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.206 3 malonyl-CoA + hexanoyl-CoA Cannabis sativa
-
 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.206 Cannabis sativa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.206 flower
-
 Cannabis sativa
-
2.3.1.206 inflorescence very high levels of cannabinoids in the flower tops Cannabis sativa
-
2.3.1.206 leaf upper Cannabis sativa
-
2.3.1.206 additional information no activity in seeds, roots, stems, and lower leaves Cannabis sativa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.206 3 malonyl-CoA + hexanoyl-CoA
-
 Cannabis sativa 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound ?
2.3.1.206 3 malonyl-CoA + hexanoyl-CoA
-
 Cannabis sativa 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide by condensation and cyclization reactions, stilbene synthase like mechanism, overview. No formation of olivetolic acid, UV-spectrum and mass spectrometry analysis ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.206 PKS
-
 Cannabis sativa
2.3.1.206 polyketide synthase
-
 Cannabis sativa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.206 30
-
 assay at Cannabis sativa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.206 6.8
-
 assay at Cannabis sativa

General Information

EC Number General Information Comment Organism
2.3.1.206 metabolism the polyketide synthase catalyzes the first step of cannabinoid biosynthesis, leading to olivetolic acid Cannabis sativa
2.3.1.206 physiological function olivetolic acid is the first intermediate involved in the cannabinoid biosynthesis in Cannabis sativa leading to the acidic forms of the major cannabinoids such as DELTA9-tetrahydrocannabinolic acid and cannabinolic acid Cannabis sativa