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Literature summary extracted from

  • Gupta, R.; Lavollay, M.; Mainardi, J.L.; Arthur, M.; Bishai, W.R.; Lamichhane, G.
    The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin (2010), Nat. Med., 16, 466-469.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.B14 expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B14 Mycobacterium tuberculosis
-
-
-
2.3.2.B14 Mycobacterium tuberculosis CDC 1551
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.B14 Ni-NTA agarose resin column chromatography, MonoQ column chromatography, and Superdex HR10/30 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B14 2 GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala
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 Mycobacterium tuberculosis GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala 3->3 crosslinked at the mesoDapNH2 position
-
 ?
2.3.2.B14 2 GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala
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 Mycobacterium tuberculosis CDC 1551 GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala 3->3 crosslinked at the mesoDapNH2 position
-
 ?
2.3.2.B14 additional information gene MT2594 (Rv2518c) encodes an L,D–transpeptidase for synthesis of non-classical 3->3 cross-linkages Mycobacterium tuberculosis ?
-
 ?
2.3.2.B14 additional information gene MT2594 (Rv2518c) encodes an L,D–transpeptidase for synthesis of non-classical 3->3 cross-linkages Mycobacterium tuberculosis CDC 1551 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.B14 L,D-transpeptidase
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 Mycobacterium tuberculosis
2.3.2.B14 LdtMt2
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 Mycobacterium tuberculosis
2.3.2.B14 MT2594
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.2.12 malfunction loss of L,D-transpeptidase gene MT2594 does not alter susceptibility to isoniazid and D-cycloserine, but is associated with increased susceptibility to amoxicillin in the presence of clavulanic acid Mycobacterium tuberculosis
2.3.2.12 physiological function the LdtMt2 protein is required for virulence and resistance to amoxicillin Mycobacterium tuberculosis