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Literature summary extracted from

  • Pino, P.; Aeby, E.; Foth, B.J.; Sheiner, L.; Soldati, T.; Schneider, A.; Soldati-Favre, D.
    Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA Met formylation in Apicomplexa (2010), Mol. Microbiol., 76, 706-718.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.9 possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively, and both gene products are predicted to carry a bipartite targeting signal Toxoplasma gondii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.9 apicoplast both the methionyl-tRNA formyltransferase and peptide deformylase are localized to the apicoplast only Toxoplasma gondii 20011
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.9 10-formyltetrahydrofolate + L-methionyl-tRNAfMet Toxoplasma gondii
-
 tetrahydrofolate + N-formylmethionyl-tRNAfMet
-
 ?
2.1.2.9 10-formyltetrahydrofolate + L-methionyl-tRNAfMet Toxoplasma gondii RH
-
 tetrahydrofolate + N-formylmethionyl-tRNAfMet
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.9 Toxoplasma gondii
-
 possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively
-
2.1.2.9 Toxoplasma gondii RH
-
 possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.9 tachyzoite
-
 Toxoplasma gondii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.9 10-formyltetrahydrofolate + L-methionyl-tRNAfMet
-
 Toxoplasma gondii tetrahydrofolate + N-formylmethionyl-tRNAfMet
-
 ?
2.1.2.9 10-formyltetrahydrofolate + L-methionyl-tRNAfMet
-
 Toxoplasma gondii RH tetrahydrofolate + N-formylmethionyl-tRNAfMet
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.9 FMT
-
 Toxoplasma gondii
2.1.2.9 methionyl-tRNA formyltransferase
-
 Toxoplasma gondii

General Information

EC Number General Information Comment Organism
2.1.2.9 metabolism formylmethionine-independent initiation of translation in apicomplexans, the requirement for an initiation by a specialized tRNA charged with formylmethionine is bypassed in the mitochondrion of these parasites, the formylated methionine used during initiation is deformylated on the nascent peptide by a peptide deformylase Toxoplasma gondii
2.1.2.9 additional information in Toxoplasma gondii the absence of mitochondrial tRNA genes is compensated for by the import of cytosolic eukaryotic tRNAs. Although all compartments require a complete set of charged tRNAs, the apicomplexan nuclear genomes do not hold sufficient aminoacyl-tRNA synthetase genes to be targeted individually to each compartment. The absence of tRNAMet formyltransferase and peptide deformylase implies that the requirement for a specialized formylmethionyl-tRNAMet for translation initiation is bypassed in the mitochondrion Toxoplasma gondii