Literature summary extracted from

Puisac, B.; Ramos, M.; Arnedo, M.; Menao, S.; Gil-Rodriguez, M.C.; Teresa-Rodrigo, M.E.; Pie, A.; de Karam, J.C.; Wesselink, J.J.; Gimenez, I.; Ramos, F.J.; Casals, N.; Gomez-Puertas, P.; Hegardt, F.G.; Pie, J.
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway (2012), Mol. Biol. Rep., 39, 4777-4785.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.3.3.10	expressed in Escherichia coli BL21-Codon Plus (DE3)-RIPL cells	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.3.10	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.3.10	brain	-	Homo sapiens	-
2.3.3.10	colon	-	Homo sapiens	-
2.3.3.10	heart	-	Homo sapiens	-
2.3.3.10	kidney	-	Homo sapiens	-
2.3.3.10	leukocyte	-	Homo sapiens	-
2.3.3.10	liver	-	Homo sapiens	-
2.3.3.10	lung	-	Homo sapiens	-
2.3.3.10	ovary	-	Homo sapiens	-
2.3.3.10	pancreas	-	Homo sapiens	-
2.3.3.10	prostate gland	-	Homo sapiens	-
2.3.3.10	skeletal muscle	-	Homo sapiens	-
2.3.3.10	small intestine	-	Homo sapiens	-
2.3.3.10	spleen	-	Homo sapiens	-
2.3.3.10	testis	-	Homo sapiens	-
2.3.3.10	thymus	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	-	Homo sapiens	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.3.10	HMG-CoA synthase	-	Homo sapiens
2.3.3.10	HMGCS2	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)