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Literature summary extracted from

  • Bussieres, S.; Cantin, L.; Desbat, B.; Salesse, C.
    Binding of a truncated form of lecithin:retinol acyltransferase and its N- and C-terminal peptides to lipid monolayers (2012), Langmuir, 28, 3516-3523.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.135 recombinant expression of His-tagged LRAT Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.135 additional information construction of a truncated enzyme version, tLRAT, that shows enzyme activity, but leads to physiological dysfunction of the protein by causing retinis pigmentosa Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.135 membrane bound, membrane topology model of LRAT using I-TASSER, membrane interaction probes of LRAT and truncated LRAT with phospholipid monolayers, circular dichroism, overview Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.135 20900
-
 x * 20900 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] Homo sapiens
-
 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.135 recombinant His-tagged LRAT by affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 eye
-
 Homo sapiens
-
2.3.1.135 intestine
-
 Homo sapiens
-
2.3.1.135 liver
-
 Homo sapiens
-
2.3.1.135 retinal pigment epithelium
-
 Homo sapiens
-
2.3.1.135 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein]
-
 Homo sapiens 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.135 ? x * 20900 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin:retinol acyltransferase
-
 Homo sapiens
2.3.1.135 LRAT
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.135 physiological function lecithin:retinol acyltransferase, LRAT, is a membrane-bound protein that plays an essential function in the visual cycle. It catalyzes the esterification of retinol into retinyl esters in the retinal pigment epithelium as well as in other tissues including testis, liver, and intestine Homo sapiens