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Literature summary extracted from
- The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis (1999), J. Mol. Biol., 289, 981-990.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.18.1.6 | expressed in Escherichia coli BL21(DE3) cells | Bos taurus |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.18.1.6 | hanging drop vapor diffusion method, using 12% (w/v) PEG-8000 in 50 mM sodium cacodylate (pH 6.5), 100 mM calcium acetate | Bos taurus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.18.1.6 | mitochondrion | - |
Bos taurus | 5739 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.18.1.6 | 51000 | - |
1 * 51000, X-ray crystallography | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.18.1.6 | Bos taurus | P08165 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.18.1.6 | ion exchange chromatography and 2'-5'-ADP-Sepharose column chromatography | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.18.1.6 | adrenal gland | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.18.1.6 | oxidized adrenodoxin + NADPH + H+ | - |
Bos taurus | reduced adrenodoxin + NADP+ | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.18.1.6 | monomer | 1 * 51000, X-ray crystallography | Bos taurus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.18.1.6 | AdR | - |
Bos taurus |
| 1.18.1.6 | adrenodoxin reductase | - |
Bos taurus |
| 1.18.1.6 | NADPH:adrenal ferredoxin oxidoreductase | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.18.1.6 | FAD | - |
Bos taurus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.18.1.6 | physiological function | the enzyme is involved in the biosynthesis of all steroid hormones | Bos taurus |
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Release 2023.1 (January 2023)
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