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Literature summary extracted from

  • Brand, S.; Cleghorn, L.A.; McElroy, S.P.; Robinson, D.A.; Smith, V.C.; Hallyburton, I.; Harrison, J.R.; Norcross, N.R.; Spinks, D.; Bayliss, T.; Norval, S.; Stojanovski, L.; Torrie, L.S.; Frearson, J.A.; Brenk, R.; Fairlamb, A.H.; Ferguson, M.A.; Read, K.D.; Wyatt, P.G.; Gilbert, I.H.
    Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors (2012), J. Med. Chem., 55, 140-152.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.97 drug development the enzyme N-myristoyltransferase represents a promising drug target Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 1-acetyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-5-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 2,6-dichloro-4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 2,6-dichloro-4-[6-(piperazin-1-yl)pyridin-3-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 2-oxo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 3',5'-dichloro-4'-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]biphenyl-3-carboxamide
-
 Trypanosoma brucei
2.3.1.97 3,5-dichloro-3'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 3,5-dichloro-3'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 3,5-dichloro-4'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 3,5-dichloro-4'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 3-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-(1H-pyrazol-1-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-N-(2-methylpropyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-N-methyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-bromo-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-(1H-pyrazol-3-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-(2-methylpyridin-3-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-(pyridin-3-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-phenylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-methoxy-2,3,6-trimethyl-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 4-[(4-bromophenoxy)methyl]-1,3,5-trimethyl-1H-pyrazole
-
 Trypanosoma brucei
2.3.1.97 4-[[(4-bromophenyl)sulfonyl]methyl]-1,3,5-trimethyl-1H-pyrazole
-
 Trypanosoma brucei
2.3.1.97 6-(2-methyl-1,3-thiazol-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-(benzylamino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-(morpholin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-([2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-chloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[(1H-indol-5-ylmethyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[2-(4-methylpiperazin-1-yl)ethylamino]pyridine-3-sulfonic acid (1,3,5-trimethyl-1H-pyrazol-4-yl)amide
-
 Trypanosoma brucei
2.3.1.97 6-[3-(piperazin-1-yl)piperidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[3-(piperazin-1-yl)pyrrolidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(1-methylpiperidin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(1H-imidazol-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(4-benzylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(4-methylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(4-phenylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(morpholin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(piperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[2-(piperidin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[3-(dimethylamino)propyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 6-[[4-[(dimethylamino)methyl]benzyl](methyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 DDD85646
-
 Homo sapiens
2.3.1.97 DDD85646
-
 Trypanosoma brucei
2.3.1.97 N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(1-propyl-3,5-dimethyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(3,5-dimethyl-1-propyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(3,5-dimethyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(4-bromobenzyl)-1,3,5-trimethyl-1H-pyrazol-4-amine
-
 Trypanosoma brucei
2.3.1.97 N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide
-
 Trypanosoma brucei
2.3.1.97 N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-(imidazo[1,2-a]pyridin-3-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-benzyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-[1,3-dimethyl-5-(morpholin-4-yl)-1H-pyrazol-4-yl]-4-methoxy-2,3,6-trimethylbenzenesulfonamide
-
 Trypanosoma brucei
2.3.1.97 N-[4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]phenyl]acetamide
-
 Trypanosoma brucei
2.3.1.97 tert-butyl 4-[2-([5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]pyridin-2-yl]amino)ethyl]piperazine-1-carboxylate
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Homo sapiens
-
 isozyme NMT-1
-
2.3.1.97 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + peptide CAP5.5 N-myristoylation of the synthetic peptide CAP5.5, derived from the N-terminus of the Trypanosoma brucei CAP5.5 protein Homo sapiens CoA + N-myristoyl-peptide CAP5.5
-
 ?
2.3.1.97 myristoyl-CoA + peptide CAP5.5 N-myristoylation of the synthetic peptide CAP5.5, derived from the N-terminus of the Trypanosoma brucei CAP5.5 protein Trypanosoma brucei CoA + N-myristoyl-peptide CAP5.5
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 N-myristoyltransferase
-
 Homo sapiens
2.3.1.97 N-myristoyltransferase
-
 Trypanosoma brucei
2.3.1.97 NMT
-
 Trypanosoma brucei
2.3.1.97 NMT-1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.97 22
-
 assay at room temperature Homo sapiens
2.3.1.97 22
-
 assay at room temperature Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.97 7.4
-
 assay at Homo sapiens
2.3.1.97 7.4
-
 assay at Trypanosoma brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.97 0.000002
-
 pH 7.4, 22°C Trypanosoma brucei 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
2.3.1.97 0.000005
-
 pH 7.4, 22°C Trypanosoma brucei 3,5-dichloro-3'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
2.3.1.97 0.00002
-
 pH 7.4, 22°C Trypanosoma brucei 3,5-dichloro-3'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
2.3.1.97 0.00003
-
 pH 7.4, 22°C Trypanosoma brucei 6-[3-(piperazin-1-yl)piperidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.00003
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(1-methylpiperidin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.000034
-
 pH 7.4, 22°C Trypanosoma brucei 4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
2.3.1.97 0.00011
-
 pH 7.4, 22°C Trypanosoma brucei 6-[3-(piperazin-1-yl)pyrrolidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.00011
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(4-methylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.00014
-
 pH 7.4, 22°C Trypanosoma brucei 6-[2-(4-methylpiperazin-1-yl)ethylamino]pyridine-3-sulfonic acid (1,3,5-trimethyl-1H-pyrazol-4-yl)amide
2.3.1.97 0.00029
-
 pH 7.4, 22°C Trypanosoma brucei 2,6-dichloro-4-[6-(piperazin-1-yl)pyridin-3-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.00033
-
 pH 7.4, 22°C Trypanosoma brucei 6-[(1H-indol-5-ylmethyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.00036
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[4-[(dimethylamino)methyl]benzyl](methyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.0009
-
 pH 7.4, 22°C Trypanosoma brucei 3',5'-dichloro-4'-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]biphenyl-3-carboxamide
2.3.1.97 0.001
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(4-phenylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.001
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(piperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.001
-
 pH 7.4, 22°C Trypanosoma brucei 6-([2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.001
-
 pH 7.4, 22°C Trypanosoma brucei 2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.0012
-
 pH 7.4, 22°C Trypanosoma brucei 3,5-dichloro-4'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
2.3.1.97 0.0013
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(1H-imidazol-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.0013
-
 pH 7.4, 22°C Trypanosoma brucei 6-(benzylamino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.0019
-
 pH 7.4, 22°C Trypanosoma brucei 6-(morpholin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.0021
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[3-(dimethylamino)propyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.0028
-
 pH 7.4, 22°C Trypanosoma brucei N-[4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]phenyl]acetamide
2.3.1.97 0.0033
-
 pH 7.4, 22°C Trypanosoma brucei 2-oxo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide
2.3.1.97 0.0043
-
 pH 7.4, 22°C Trypanosoma brucei 2,6-dichloro-4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.0048
-
 pH 7.4, 22°C Trypanosoma brucei 4-(1H-pyrazol-1-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.0086
-
 pH 7.4, 22°C Trypanosoma brucei 1-acetyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-5-sulfonamide
2.3.1.97 0.01
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(4-benzylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.01
-
 pH 7.4, 22°C Trypanosoma brucei tert-butyl 4-[2-([5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]pyridin-2-yl]amino)ethyl]piperazine-1-carboxylate
2.3.1.97 0.011
-
 pH 7.4, 22°C Trypanosoma brucei 3,5-dichloro-4'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
2.3.1.97 0.012
-
 pH 7.4, 22°C Trypanosoma brucei 6-(2-methyl-1,3-thiazol-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.012
-
 pH 7.4, 22°C Trypanosoma brucei N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.014
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(piperidin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.026
-
 pH 7.4, 22°C Trypanosoma brucei 6-chloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.028
-
 pH 7.4, 22°C Trypanosoma brucei 3-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.032
-
 pH 7.4, 22°C Trypanosoma brucei 4-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.038
-
 pH 7.4, 22°C Trypanosoma brucei 6-[[2-(morpholin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
2.3.1.97 0.042
-
 pH 7.4, 22°C Trypanosoma brucei 4-[[(4-bromophenyl)sulfonyl]methyl]-1,3,5-trimethyl-1H-pyrazole
2.3.1.97 0.049
-
 pH 7.4, 22°C Trypanosoma brucei 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
2.3.1.97 0.1
-
 above, pH 7.4, 22°C Trypanosoma brucei N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide
2.3.1.97 0.1
-
 above, pH 7.4, 22°C Trypanosoma brucei N-(4-bromobenzyl)-1,3,5-trimethyl-1H-pyrazol-4-amine
2.3.1.97 0.1
-
 above, pH 7.4, 22°C Trypanosoma brucei 4-[(4-bromophenoxy)methyl]-1,3,5-trimethyl-1H-pyrazole
2.3.1.97 0.1
-
 above, pH 7.4, 22°C Trypanosoma brucei 4-bromo-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide
2.3.1.97 0.1
-
 above, pH 7.4, 22°C Trypanosoma brucei N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide