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Literature summary extracted from

  • Chalaris, A.; Adam, N.; Sina, C.; Rosenstiel, P.; Lehmann-Koch, J.; Schirmacher, P.; Hartmann, D.; Cichy, J.; Gavrilova, O.; Schreiber, S.; Jostock, T.; Matthews, V.; Haesler, R.; Becker, C.; Neurath, M.; Reiss, K.; Saftig, P.; Scheller, J.; Rose-John, S.
    Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice (2010), J. Exp. Med., 207, 1617-1624.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.86 medicine ADAM17 is a potential drug target in tumor necrosis factor and/or epidermal growth factor receptor–dependent pathologies in inflammation and cancer Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.86 epidermal growth factor receptor + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 L-selectin + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 proTNF-alpha + H2O Mus musculus
-
 soluble TNF-alpha + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 epidermal growth factor receptor + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 L-selectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 a disintegrin and metalloprotease 17
-
 Mus musculus
3.4.24.86 ADAM17
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.24.86 Mus musculus ADAM17 is expressed in most tissues and is up-regulated during inflammation and cancer up

General Information

EC Number General Information Comment Organism
3.4.24.86 malfunction ADAM17-deficient mice are not viable. Mice with dramatically reduced ADAM17 levels show substantially increased susceptibility to inflammation in dextran sulfate sodium colitis and develop eye, heart, and skin defects Mus musculus
3.4.24.86 physiological function ADAM17 is needed for vital regenerative activities during the immune response. ADAM17 is not crucial for developmental Notch or Notch ligand function in vivo Mus musculus