Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
    Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity (2013), J. Enzyme Inhib. Med. Chem., 28, 565-568.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 adriamycin cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.0035 mM, for A-549 cell 0.0018 mM, for HL-60 cell 0.0008 mM Homo sapiens
2.3.1.85 cerulenin
-
 Gallus gallus
2.3.1.85 ginkgolic acid C15:1 DELTA8 and DELTA10 isomers, at ratio 1:2 Gallus gallus
2.3.1.85 ginkgolic acid C15:1 DELTA8 and DELTA10 isomers, at ratio 1:2. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.146 mM, for A-549 cell 0.066 mM, for HL-60 cell 0.005 mM Homo sapiens
2.3.1.85 ginkgolic acid C17:1 double bond positions not specified Gallus gallus
2.3.1.85 ginkgolic acid C17:1 double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.093 mM, for A-549 cell 0.050 mM, for HL-60 cell 0.004 mM Homo sapiens
2.3.1.85 ginkgolic acid C17:2 double bond positions not specified Gallus gallus
2.3.1.85 ginkgolic acid C17:2 double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.108 mM, for A-549 cell 0.056 mM, for HL-60 cell 0.004 mM Homo sapiens
2.3.1.85 luteolin
-
 Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Gallus gallus
-
-
-
2.3.1.85 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.85
-
 Gallus gallus
2.3.1.85
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.85 A-549 cell
-
 Homo sapiens
-
2.3.1.85 HL-60 cell
-
 Homo sapiens
-
2.3.1.85 liver
-
 Gallus gallus
-
2.3.1.85 MCF-7 cell
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.85 0.009
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C17:2
2.3.1.85 0.01
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C17:1
2.3.1.85 0.013
-
 pH 7.0, 37°C Gallus gallus cerulenin
2.3.1.85 0.017
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C15:1
2.3.1.85 0.062
-
 pH 7.0, 37°C Gallus gallus luteolin