EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.17 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.17 | 2-phenyl-4H-benzo[h]chromen-4-one | - |
Homo sapiens | |
2.4.1.17 | bupropion | - |
Homo sapiens | |
2.4.1.17 | cyclosporine A | - |
Homo sapiens | |
2.4.1.17 | dextromethorphan | - |
Homo sapiens | |
2.4.1.17 | diclofenac | - |
Homo sapiens | |
2.4.1.17 | ketoconazole | - |
Homo sapiens | |
2.4.1.17 | midazolam | - |
Homo sapiens | |
2.4.1.17 | oleandomycin | - |
Homo sapiens | |
2.4.1.17 | Omeprazole | - |
Homo sapiens | |
2.4.1.17 | paclitaxel | - |
Homo sapiens | |
2.4.1.17 | quinidine | - |
Homo sapiens | |
2.4.1.17 | testosterone | - |
Homo sapiens | |
2.4.1.17 | Tolbutamide | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.17 | 0.013 | - |
midazolam | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.021 | - |
beta-estradiol | isoform UGT1A1, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.056 | - |
diclofenac | isoform UGT2B10, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.069 | - |
diclofenac | isoform UGT2B7, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.084 | - |
1-naphthol | isoform UGT1A6, pH 7.4, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.17 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.17 | 1-naphthol + UDP-alpha-D-glucuronate | - |
Homo sapiens | 1-naphthyl-O-glucuronide + UDP | - |
? | |
2.4.1.17 | beta-estradiol + UDP-alpha-D-glucuronate | - |
Homo sapiens | beta-estradiol-3-glucuronide + UDP | - |
? | |
2.4.1.17 | diclofenac + UDP-alpha-D-glucuronate | - |
Homo sapiens | diclofenac D-glucuronide + UDP | - |
? | |
2.4.1.17 | midazolam + UDP-alpha-D-glucuronate | - |
Homo sapiens | midazolam D-glucuronide + UDP | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.1.17 | 0.0041 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
2.4.1.17 | 0.0049 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
2.4.1.17 | 0.019 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
2.4.1.17 | 0.02 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
2.4.1.17 | 0.022 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
2.4.1.17 | 0.023 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | cyclosporine A | |
2.4.1.17 | 0.023 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
2.4.1.17 | 0.023 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | midazolam | |
2.4.1.17 | 0.026 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | midazolam | |
2.4.1.17 | 0.038 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
2.4.1.17 | 0.043 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | testosterone | |
2.4.1.17 | 0.044 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
2.4.1.17 | 0.046 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | diclofenac | |
2.4.1.17 | 0.048 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | cyclosporine A | |
2.4.1.17 | 0.056 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | Omeprazole | |
2.4.1.17 | 0.058 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
2.4.1.17 | 0.059 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
2.4.1.17 | 0.06 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
2.4.1.17 | 0.062 | - |
isoform UGT2B10, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | dextromethorphan | |
2.4.1.17 | 0.067 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
2.4.1.17 | 0.074 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
2.4.1.17 | 0.088 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | bupropion | |
2.4.1.17 | 0.089 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | dextromethorphan | |
2.4.1.17 | 0.106 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | midazolam | |
2.4.1.17 | 0.147 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | midazolam | |
2.4.1.17 | 0.149 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
2.4.1.17 | 0.152 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | bupropion | |
2.4.1.17 | 0.155 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | diclofenac | |
2.4.1.17 | 0.165 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | testosterone | |
2.4.1.17 | 0.166 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | quinidine | |
2.4.1.17 | 0.185 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | Omeprazole | |
2.4.1.17 | 0.192 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | diclofenac | |
2.4.1.17 | 0.272 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
2.4.1.17 | 0.281 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | Tolbutamide |