EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.86 | GM6001 | poor inhibitive effectiveness on TACE | Homo sapiens | |
3.4.24.86 | N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.86 | Zn2+ | a zinc metalloprotease | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.86 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.86 | (7-methoxycoumarin-4-yl)acetyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.86 | Dpa-SPLAQAVRSSSR-NH2 + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.86 | ADAM-17 | - |
Homo sapiens |
3.4.24.86 | TACE | - |
Homo sapiens |
3.4.24.86 | TNF-alpha converting enzyme | - |
Homo sapiens |
3.4.24.86 | tumour necrosis factor alpha-converting enzyme | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.24.86 | 0.000175 | - |
in 25 mM Tris-HCl buffer, pH 9.0, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C | Homo sapiens | N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide | |
3.4.24.86 | 0.000317 | - |
in 25 mM Tris-HCl buffer, pH 9, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C | Homo sapiens | GM6001 |