Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhao, Y.; Yu, J.; Gu, J.; Huang, W.
    The evaluation of inhibitive effectiveness of the tumour necrosis factor-alpha converting enzyme selective inhibitors by HPLC (2011), J. Enzyme Inhib. Med. Chem., 26, 181-187.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 GM6001 poor inhibitive effectiveness on TACE Homo sapiens
3.4.24.86 N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.86 Zn2+ a zinc metalloprotease Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 (7-methoxycoumarin-4-yl)acetyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2 + H2O
-
Homo sapiens ?
-
?
3.4.24.86 Dpa-SPLAQAVRSSSR-NH2 + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM-17
-
Homo sapiens
3.4.24.86 TACE
-
Homo sapiens
3.4.24.86 TNF-alpha converting enzyme
-
Homo sapiens
3.4.24.86 tumour necrosis factor alpha-converting enzyme
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.86 0.000175
-
in 25 mM Tris-HCl buffer, pH 9.0, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C Homo sapiens N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide
3.4.24.86 0.000317
-
in 25 mM Tris-HCl buffer, pH 9, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C Homo sapiens GM6001