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Literature summary extracted from

  • Hanfrey, C.C.; Pearson, B.M.; Hazeldine, S.; Lee, J.; Gaskin, D.J.; Woster, P.M.; Phillips, M.A.; Michael, A.J.
    Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota (2011), J. Biol. Chem., 286, 43301-43312.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.4.1.B4 additional information deletion of the gene encoding carboxynorspermidine dehydrogenase. The CASDH gene deletion strain grows normally Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.B4 L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ Campylobacter jejuni
-
 carboxynorspermidine + NADP+ + H2O
-
 ?
4.1.1.96 additional information Campylobacter jejuni the Campylobacter jejuni enzyme is a carboxyspermidine decarboxylase and not a carboxynorspermidine decarboxylase in vivo and is essential for spermidine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.B4 Campylobacter jejuni A0A1J6U6V7
-
-
1.5.1.43 Campylobacter jejuni
-
-
-
4.1.1.96 Campylobacter jejuni
-
 NCTC11828
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.B4 L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
-
 Campylobacter jejuni carboxynorspermidine + NADP+ + H2O
-
 ?
1.5.1.43 L-aspartate 4-semialdehyde + putrescine + NADPH + H+
-
 Campylobacter jejuni carboxyspermidine + H2O + NADP+
-
 ?
4.1.1.96 carboxynorspermidine the enzyme has relatively equal preference for carboxynorspermidine and carboxyspermidine Campylobacter jejuni bis(3-aminopropyl)amine + CO2
-
 ?
4.1.1.96 carboxyspermidine the enzyme has relatively equal preference for carboxynorspermidine and carboxyspermidine Campylobacter jejuni spermidine + CO2
-
 ?
4.1.1.96 additional information the Campylobacter jejuni enzyme is a carboxyspermidine decarboxylase and not a carboxynorspermidine decarboxylase in vivo and is essential for spermidine biosynthesis Campylobacter jejuni ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.1.B4 CANSDH
-
 Campylobacter jejuni
1.5.1.43 carboxyspermidine dehydrogenase
-
 Campylobacter jejuni
1.5.1.43 CASDH
-
 Campylobacter jejuni
4.1.1.96 CANSDC
-
 Campylobacter jejuni

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.B4 NADPH
-
 Campylobacter jejuni
1.5.1.43 NADPH
-
 Campylobacter jejuni
4.1.1.96 pyridoxal 5'-phosphate
-
 Campylobacter jejuni

General Information

EC Number General Information Comment Organism
1.4.1.B4 evolution the enzyme is found in diverse bacterial phyla, overview. orthologues encoding carboxyspermidine dehydrogenase and carboxyspermidine decarboxylase are found clustered with an array of diverse putrescine biosynthetic genes in different bacterial genomes, consistent with a role in spermidine, rather than sym-norspermidine biosynthesis Campylobacter jejuni
1.4.1.B4 malfunction the CASDH gene deletion strain grows normally Campylobacter jejuni