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Literature summary extracted from

  • Agarwal, A.K.; Sukumaran, S.; Cortes, V.A.; Tunison, K.; Mizrachi, D.; Sankella, S.; Gerard, R.D.; Horton, J.D.; Garg, A.
    Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice (2011), J. Biol. Chem., 286, 37676-37691.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.51 medicine the role of isoforms AGPAT1 or AGPAT2 in liver lipogenesis is minimal and accumulation of liver fat is primarily a consequence of insulin resistance and loss of adipose tissue in Agpat2 -/- mice Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.51 expression via recombinant adenoviruses in Agpat2 -/- mice Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.51 endoplasmic reticulum both isoforms AGPAT1 and AGPAT2 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Homo sapiens O15120
-
-
2.3.1.51 Homo sapiens Q99943
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 adipose tissue
-
 Homo sapiens
-
2.3.1.51 liver
-
 Homo sapiens
-
2.3.1.51 pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate linoleoyl-CoA is second best acyl-CoA substrate Homo sapiens CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 additional information no substrates: acyl-CoA with fatty acids shorter than C14:0 or longer than C20:0, whether saturated or unsaturated Homo sapiens ?
-
 ?
2.3.1.51 additional information no substrates: acyl-CoA with fatty acids shorter than C14:0 or longer than C20:0, whether saturated or unsaturated. Isoform AGPAT2 is rather restrictive in using 1-oleoyl-sn-glycerol 3-phosphate as acceptor substrate Homo sapiens ?
-
 ?
2.3.1.51 oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate both substrates are preferred Homo sapiens CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate 50% of the rate with oleoyl-CoA and linoleoyl-CoA Homo sapiens CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate rate is similar to oleoyl-CoA and linoleoyl-CoA Homo sapiens CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.51 AGPAT1
-
 Homo sapiens
2.3.1.51 AGPAT2
-
 Homo sapiens