Any feedback?
Literature summary extracted from
- Biochemical characterization of AtHMA6/PAA1, a chloroplast envelope Cu(I)-ATPase (2011), J. Biol. Chem., 286, 36188-36197.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.2.2.9 | expressed in Lactococcus lactis | Arabidopsis thaliana |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | D598A | inactive | Arabidopsis thaliana |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.9 | chloroplast envelope | inner membrane of the chloroplast envelope | Arabidopsis thaliana | 9941 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.9 | Ag+ | the enzyme is activated by silver ions with an apparent affinity in the micromolar range (40% activation at 0.005 mM compared to Cu+) | Arabidopsis thaliana |  |
| 7.2.2.9 | Cu+ | the enzyme is preferentially activated by monovalent copper ions with an apparent affinity in the micromolar range (100% activation at 0.005 mM) | Arabidopsis thaliana | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.9 | Arabidopsis thaliana | Q9SZC9 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | phosphoprotein | PAA1 is phosphorylated from ATP in the presence of monovalent metals (only CuCl2 and AgNO3). The presence of EGTA does not affect the phosphorylation levels | Arabidopsis thaliana |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.9 | ATP + H2O + Cu+/in | - |
Arabidopsis thaliana | ADP + phosphate + Cu+/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | copper-transporting ATPase | - |
Arabidopsis thaliana |
| 7.2.2.9 | Cu(I)-ATPase | - |
Arabidopsis thaliana |
| 7.2.2.9 | PAA1 | - |
Arabidopsis thaliana |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | physiological function | PAA1 is a high affinity Cu(I) transporter of the chloroplast envelope. The sensitivity to copper and silver correlates with the presence of a functional enzyme | Arabidopsis thaliana |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
