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Literature summary extracted from

  • Bessadok, A.; Garcia, E.; Jacquet, H.; Martin, S.; Garrigues, A.; Loiseau, N.; Andre, F.; Orlowski, S.; Vivaudou, M.
    Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins (2011), J. Biol. Chem., 286, 3552-3569.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 Diazoxide about 55% increase in ATPase activity, half-activation concentration is 0.6 mM Cricetulus griseus
7.6.2.2 glibenclamide augments the ATPase activity with a maximum attained near 100 microM Cricetulus griseus
7.6.2.2 meglitinide increases ATPase activity, maximum activation levels of 70% Cricetulus griseus
7.6.2.2 additional information ligands of sulfonylurea receptor SUR also interact with P-plycoprotein, due to structural similarity between drug binding domains in the two proteins Cricetulus griseus
7.6.2.2 P1075 about 55% increase in ATPase activity, half-activation concentration is 0.036 mM Cricetulus griseus
7.6.2.2 SR47063 100% increase in ATPase activity, half-activation concentration is 1.5 mM Cricetulus griseus
7.6.2.2 Tolbutamide increases ATPase activity, with maximum activation levels of 70% Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Cricetulus griseus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 DC-3F/ADX cell selected from spontaneously transformed Chinese hamster lung fibroblast DC-3F on the basis of resistance to actinomycin D Cricetulus griseus
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