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Literature summary extracted from

  • Frankel, M.B.; Hendrickx, A.P.; Missiakas, D.M.; Schneewind, O.
    LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly (2011), J. Biol. Chem., 286, 32593-32605.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.28 expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.28 envelope
-
 Staphylococcus aureus 31975
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.28 peptidoglycan + H2O Staphylococcus aureus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.28 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.28 Ni-NTA Sepharose column chromatography, gel filtration Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.28 peptidoglycan + H2O
-
 Staphylococcus aureus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.28 LytN LytN harbors LysM and histidine-dependent amidohydrolase/peptidase domains, the latter of which functions as both an N-acetylmuramoyl-L-alanine amidase and D-alanyl-glycine endopeptidase Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.5.1.28 physiological function LytN secretion into the cross-wall promotes peptidoglycan separation and completion of the staphylococcal cell cycle. LytN is required for proper staphylococcal growth. Overexpression of LytN triggers lysis of the staphylococcal cross-wall Staphylococcus aureus