Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Skipwith, C.G.; Cao, W.; Zheng, X.L.
    Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress (2010), J. Biol. Chem., 285, 28596-28603.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.87 additional information in the absence of factor VIII, lyophilized platelets increase the formation of cleavage product by 2-3fold under fluid shear stresses. However, in the presence of physiological concentration of factor VIII (1 nM), the formation of von Willebrand factor cleavage product increases dramatically as a function of increasing platelets (150000 per microliter) with the maximal rate enhancement of about 8fold Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
Homo sapiens