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Literature summary extracted from

  • Grilley, M.; Stock, S.; Dickson, R.; Lester, R.; Takemoto, J.
    Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae (1998), J. Biol. Chem., 273, 11062-11068.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.18.5 membrane integral membrane protein Saccharomyces cerevisiae 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.5 Iron a diiron binding enzyme Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.5 Saccharomyces cerevisiae
-
-
-
1.14.18.5 Saccharomyces cerevisiae W303C
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.5 dihydroceramide + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae ?
-
 ?
1.14.18.5 dihydroceramide + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae W303C ?
-
 ?
1.14.18.5 DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae phytosphingosine + acceptor + H2O
-
 ?
1.14.18.5 DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae W303C phytosphingosine + acceptor + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.5 DHS hydroxylase
-
 Saccharomyces cerevisiae
1.14.18.5 dihydroceramide hydrolase
-
 Saccharomyces cerevisiae
1.14.18.5 SUR2
-
 Saccharomyces cerevisiae
1.14.18.5 SYR2
-
 Saccharomyces cerevisiae
1.14.18.5 Syr2p
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.14.18.5 malfunction yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine Saccharomyces cerevisiae
1.14.18.5 physiological function SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis Saccharomyces cerevisiae