EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.4.2.2 | additional information | generation of diverse liv gene deletion mutant strains, DELTAlivJ mutant shows a 10fold reduction in leucine transport, DELTAlivK mutant shows 43fold reduction compared to the wild-type activity, deletion of both livJ and livK reduces the transport of leucine to over 200fold lower than that for wild-type cells. Also deletion of other liv gene either individually, e.g., DELTAlivH, DELTAlivM, DELTAlivG, or DELTAlivF, or as paired double mutants essentially abolishes transport of leucine. Deletion of both livJ and livK as well as both permeases or ATPases results in abolishment of transport of isoleucine and valine | Campylobacter jejuni |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.4.2.2 | ATP + H2O + L-leucine/out | Campylobacter jejuni | specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine | ADP + phosphate + L-leucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-leucine/out | Campylobacter jejuni 81-176 | specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine | ADP + phosphate + L-leucine/in | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.4.2.2 | Campylobacter jejuni | - |
clinical isolate, live genes encoded in the liv operon | - |
7.4.2.2 | Campylobacter jejuni 81-176 | - |
clinical isolate, live genes encoded in the liv operon | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.4.2.2 | ATP + H2O + L-isoleucine/out | 19fold less transport compared to leucine | Campylobacter jejuni | ADP + phosphate + L-isoleucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-isoleucine/out | 19fold less transport compared to leucine | Campylobacter jejuni 81-176 | ADP + phosphate + L-isoleucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-leucine/out | - |
Campylobacter jejuni | ADP + phosphate + L-leucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-leucine/out | specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine | Campylobacter jejuni | ADP + phosphate + L-leucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-leucine/out | - |
Campylobacter jejuni 81-176 | ADP + phosphate + L-leucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-leucine/out | specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine | Campylobacter jejuni 81-176 | ADP + phosphate + L-leucine/in | - |
? | |
7.4.2.2 | ATP + H2O + L-valine/out | 45fold less transport compared to leucine | Campylobacter jejuni | ADP + phosphate + L-valine/in | - |
? | |
7.4.2.2 | ATP + H2O + nonpolar amino acid/out | - |
Campylobacter jejuni | ADP + phosphate + nonpolar amino acid/in | - |
? | |
7.4.2.2 | ATP + H2O + nonpolar amino acid/out | - |
Campylobacter jejuni 81-176 | ADP + phosphate + nonpolar amino acid/in | - |
? | |
7.4.2.2 | additional information | LIV proteins are involved in transport of other branched-chain amino acids but at more modest levels than observed for leucine, comparison of activities of wild-type and mutant strains, overview | Campylobacter jejuni | ? | - |
? | |
7.4.2.2 | additional information | LIV proteins are involved in transport of other branched-chain amino acids but at more modest levels than observed for leucine, comparison of activities of wild-type and mutant strains, overview | Campylobacter jejuni 81-176 | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.4.2.2 | branched-chain amino acid transporter | - |
Campylobacter jejuni |
EC Number | Organism | Comment | Expression |
---|---|---|---|
7.4.2.2 | Campylobacter jejuni | livJ expression is not induced by leucine | additional information |
EC Number | General Information | Comment | Organism |
---|---|---|---|
7.4.2.2 | physiological function | LivJ and LivK are required for optimal commensal colonization of the chick ceca | Campylobacter jejuni |