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Literature summary extracted from

  • Gisin, J.; Mueller, A.; Pfaender, Y.; Leimkuehler, S.; Narberhaus, F.; Masepohl, B.
    A Rhodobacter capsulatus member of a universal permease family imports molybdate and other oxyanions (2010), J. Bacteriol., 192, 5943-5952.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
7.3.2.5 additional information generation of molybdate transporter mutants by random transposon Tn5 mutagenesis, phenotypes, overview. The mutants grow much better than the wild-type in the presence of 10 mM molybdate, at low Mo concentrations, mutant strains grow as well as the wild-type Rhodobacter capsulatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.3.2.5 ATP + H2O + molybdate/out Rhodobacter capsulatus
-
 ADP + phosphate + molybdate/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.3.2.5 Rhodobacter capsulatus
-
 genes modABC and perO
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.3.2.5 ATP + H2O + molybdate/out
-
 Rhodobacter capsulatus ADP + phosphate + molybdate/in
-
 ?
7.3.2.5 additional information PerO mediates uptake of molybdate, sulfate, tungstate, and vanadate Rhodobacter capsulatus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.3.2.5 ModABC
-
 Rhodobacter capsulatus
7.3.2.5 molybdate importer
-
 Rhodobacter capsulatus
7.3.2.5 oxyanion permease
-
 Rhodobacter capsulatus
7.3.2.5 PerO
-
 Rhodobacter capsulatus

Expression

EC Number Organism Comment Expression
7.3.2.5 Rhodobacter capsulatus expression of perO is independent of molybdate and sulfate availabilities up

General Information

EC Number General Information Comment Organism
7.3.2.5 evolution ModABC belongs to the family of ATP-binding cassette (ABC) transporters, while PerO is a member of the ArsB/NhaD family Rhodobacter capsulatus
7.3.2.5 malfunction during growth under Mo-replete conditions, the wild-type strain accumulates considerably more Mo than the enzyme mutant Rhodobacter capsulatus
7.3.2.5 physiological function ModABC imports molybdate in nanomolar range into the cell, another oxyanion permease, PerO, which is a general oxyanion importer, also imports molybdate in the micromolar range, overview. PerO is involved in molybdenum accumulation, but PerO is dispensable under standard growth conditions Rhodobacter capsulatus