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Literature summary extracted from

  • De Pascale, G.; Nazi, I.; Harrison, P.H.; Wright, G.D.
    beta-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents (2011), J. Antibiot., 64, 483-487.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.31 S143A mutant does not show any acetyltransferase activity. Incubation of mutant HTAH with ebelactone A and inhibitor does not generate an enzyme-inhibitor adduct Haemophilus influenzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.31 (3S,4S)-4-heptyl-3-methyloxetan-2-one
-
 Haemophilus influenzae
2.3.1.31 4-nonyloxetan-2-one
-
 Haemophilus influenzae
2.3.1.31 ebelactone A
-
 Haemophilus influenzae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.31 Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.31 acetyl-CoA + L-homoserine
-
 Haemophilus influenzae CoA + O-acetyl-L-homoserine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.31 homoserine transacetylase
-
 Haemophilus influenzae
2.3.1.31 HTA
-
 Haemophilus influenzae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.31 37
-
 assay at Haemophilus influenzae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.31 8
-
 assay at Haemophilus influenzae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.31 0.01
-
 (3S,4S)-4-heptyl-3-methyloxetan-2-one pH 7.5, 37°C Haemophilus influenzae
2.3.1.31 0.084
-
 4-nonyloxetan-2-one pH 7.5, 37°C Haemophilus influenzae
2.3.1.31 0.203
-
 ebelactone A pH 7.5, 37°C Haemophilus influenzae