Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sato, T.; Hoshino, H.; Yoshida, S.; Nakajima, M.; Hoshino, T.
    Bifunctional triterpene/sesquarterpene cyclase: Tetraprenyl-beta-curcumene cyclase is also squalene cyclase in bacillus megaterium (2011), J. Am. Chem. Soc., 133, 17540-17543.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.137 expressed in Escherichia coli Priestia megaterium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.130 all-trans-heptaprenyl diphosphate Priestia megaterium
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Bacillus amyloliquefaciens
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Bacillus atrophaeus
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Evansella cellulosilytica
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Bacillus pumilus
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Priestia megaterium 168
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Priestia megaterium 319
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate Bacillus atrophaeus 1942
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.137 Priestia megaterium
-
-
-
4.2.3.130 Bacillus amyloliquefaciens A0A563C0M5 gene ytpB
-
4.2.3.130 Bacillus atrophaeus A0A0H3E5A4 gene ytpB
-
4.2.3.130 Bacillus atrophaeus 1942 A0A0H3E5A4 gene ytpB
-
4.2.3.130 Bacillus pumilus A8FGH3 gene ytpB
-
4.2.3.130 Evansella cellulosilytica E6U1R5 gene Bcell_3320
-
4.2.3.130 Priestia megaterium D5DN48 gene BMD_4842
-
4.2.3.130 Priestia megaterium O34707 gene ytpB
-
4.2.3.130 Priestia megaterium 168 O34707 gene ytpB
-
4.2.3.130 Priestia megaterium 319 D5DN48 gene BMD_4842
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.137 additional information it is demonstrated that a tetraprenyl-beta-curcumene cyclase also cyclizes a tail-to-tail type of linear squalene into a bicyclic triterpenol, 8alpha-hydroxypolypoda-13,17,21-triene Priestia megaterium ?
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Priestia megaterium tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Bacillus amyloliquefaciens tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Bacillus atrophaeus tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Evansella cellulosilytica tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Bacillus pumilus tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Priestia megaterium 168 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Priestia megaterium 319 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Bacillus atrophaeus 1942 tetraprenyl-beta-curcumene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.137 tetraprenyl-beta-curcumene cyclase bifunctional enzyme, cyclizing both tetraprenyl-beta-curcumene and squalene in vivo Priestia megaterium

General Information

EC Number General Information Comment Organism
4.2.1.137 metabolism tetraprenyl-beta-curcumene cyclase is bifunctional, cyclizing both tetraprenyl-beta-curcumene and squalene in vivo Priestia megaterium