BRENDA - Enzyme Database show

Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus

Gazanion, E.; Seblova, V.; Votypka, J.; Vergnes, B.; Garcia, D.; Volf, P.; Sereno, D.; Int. J. Parasitol. 42, 323-327 (2012)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.5.1.19
C161A
inactive
Leishmania infantum
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.1.19
nicotinamide + H2O
Leishmania infantum
-
nicotinate + NH3
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.1.19
Leishmania infantum
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.1.19
promastigote
-
Leishmania infantum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
719619
Leishmania infantum
nicotinate + NH3
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.5.1.19
C161A
inactive
Leishmania infantum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.1.19
nicotinamide + H2O
Leishmania infantum
-
nicotinate + NH3
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.1.19
promastigote
-
Leishmania infantum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
719619
Leishmania infantum
nicotinate + NH3
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.5.1.19
physiological function
Leishmania infantum nicotinamidase is required for late-stage intravectorial development in Phlebotomus perniciosus. Nicotinamide degradation by the parasitic nicotinamidase is important during blood meal digestion and especially for establishing mature infection after blood meal defecation
Leishmania infantum
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.5.1.19
physiological function
Leishmania infantum nicotinamidase is required for late-stage intravectorial development in Phlebotomus perniciosus. Nicotinamide degradation by the parasitic nicotinamidase is important during blood meal digestion and especially for establishing mature infection after blood meal defecation
Leishmania infantum