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Literature summary extracted from

  • Gazanion, E.; Seblova, V.; Votypka, J.; Vergnes, B.; Garcia, D.; Volf, P.; Sereno, D.
    Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus (2012), Int. J. Parasitol., 42, 323-327.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.19 C161A inactive Leishmania infantum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.19 nicotinamide + H2O Leishmania infantum
-
 nicotinate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.19 Leishmania infantum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.19 promastigote
-
 Leishmania infantum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.19 nicotinamide + H2O
-
 Leishmania infantum nicotinate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.19 Pnc1
-
 Leishmania infantum

General Information

EC Number General Information Comment Organism
3.5.1.19 physiological function Leishmania infantum nicotinamidase is required for late-stage intravectorial development in Phlebotomus perniciosus. Nicotinamide degradation by the parasitic nicotinamidase is important during blood meal digestion and especially for establishing mature infection after blood meal defecation Leishmania infantum