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Literature summary extracted from

  • Castillo, R.; Saier, M.H.
    Functional promiscuity of homologues of the bacterial ArsA ATPases (2010), Int. J. Microbiol., 2010, 187373.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.3.2.7 ArsD ArsD is a metallochaperone which sequesters arsenite and antimonite and transfers them to the ArsA ATPase increasing the apparent affinity of ArsA for its substrates and lowering the concentration of free As(III) and Sb(III) in the cytosol Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.3.2.7 gene arsA, phylogenetic analysis with detailed analysis of clustering in the superfamily, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.3.2.7 ATP + H2O + antimonite/in Escherichia coli
-
 ADP + phosphate + antimonite/out
-
 ?
7.3.2.7 ATP + H2O + arsenite/in Escherichia coli
-
 ADP + phosphate + arsenite/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.3.2.7 Escherichia coli
-
 genes arsA and arsB
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.3.2.7 ATP + H2O + antimonite/in
-
 Escherichia coli ADP + phosphate + antimonite/out
-
 ?
7.3.2.7 ATP + H2O + arsenite/in
-
 Escherichia coli ADP + phosphate + arsenite/out
-
 ?

Subunits

EC Number Subunits Comment Organism
7.3.2.7 More subunit ArsA exhibuts ATPase activity and subunit ArsB is a 12 alpha-helix transmembrane spanning pump extruding As(III) and Sb(III) Escherichia coli

General Information

EC Number General Information Comment Organism
7.3.2.7 evolution phylogenetic analysis of gene arsA and prokaryotic and eukaryotic ArsA homologues with detailed analysis of clustering in the superfamily, overview Escherichia coli
7.3.2.7 physiological function subunit ArsA exhibuts ATPase activity and subunit ArsB is a 12 alpha-helix transmembrane spanning pump extruding As(III) and Sb(III). Transport via ArsB can be energized by the pmf or by forming an oxyanion translocating complex with the catalytic ArsA subunit, coupling ATP hydrolysis to efflux Escherichia coli