Literature summary extracted from
OMeara, M.M.; Zhang, F.; Hobert, O.
Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49 (2010), Genetics, 186, 1497-1502.
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
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Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.1.48 |
Caenorhabditis elegans |
- |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
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Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.3.1.48 |
Lsy-12 |
- |
Caenorhabditis elegans |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.3.1.48 |
physiological function |
a histone modifying complex, composed of the Lsy-12 MYST-type histone acetyltransferase, the Ing-family plant homeodomain protein Lsy-13, and plant homeodomain/bromodomain protein Lin-49, is required to first initiate and then actively maintain lateralized gene expression in the gustatory system. A combination of transcription factors, which recognize DNA in a sequence-specific manner, and a histone modifying enzyme complex are responsible for inducing and maintaining neuronal laterality. In lsy-12 mutants the normally ASER-specific gcy-5 gene is expressed bilaterally from the onset of its expression in threefold embryos |
Caenorhabditis elegans |