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Literature summary extracted from

  • Park, J.; Yoon, S.
    Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase (2010), Food Sci. Biotechnol., 19, 859-864.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.5.1.23 medicine inhibition of acid ceramidase is useful in cancer treatment Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.23 expressed in CHO cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.23 (1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
-
 Homo sapiens
3.5.1.23 (1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
-
 Mus musculus
3.5.1.23 (1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol
-
 Homo sapiens
3.5.1.23 (1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol
-
 Mus musculus
3.5.1.23 1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Homo sapiens
3.5.1.23 1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Mus musculus
3.5.1.23 1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Homo sapiens
3.5.1.23 1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Mus musculus
3.5.1.23 N-oleoylethanolamine
-
 Homo sapiens
3.5.1.23 N-oleoylethanolamine
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.23 lysosome
-
 Mus musculus 5764
-
3.5.1.23 lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.23 13000
-
 x * 40000 + 1 * 13000 Homo sapiens
3.5.1.23 40000
-
 x * 40000 + 1 * 13000 Homo sapiens
3.5.1.23 53000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Mus musculus
-
 sphingosine + fatty acid
-
 r
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 r
3.5.1.23 N-lauroylsphingosine + H2O Homo sapiens
-
 laurate + sphingosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens
-
-
-
3.5.1.23 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.1.23 glycoprotein
-
 Mus musculus
3.5.1.23 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.23 concanavalin A column chromatography, Blue Sepharose column chromatography, and Superose 12 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 oocyte acid ceramidase protein is observed in unfertilized eggs Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Mus musculus sphingosine + fatty acid
-
 r
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 r
3.5.1.23 N-lauroylsphingosine + H2O
-
 Homo sapiens laurate + sphingosine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.23 heterodimer x * 40000 + 1 * 13000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 acid ceramidase
-
 Mus musculus
3.5.1.23 acid ceramidase
-
 Homo sapiens
3.5.1.23 N-acylsphingosine deacylase
-
 Mus musculus
3.5.1.23 N-acylsphingosine deacylase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.5.1.23 Mus musculus acid ceramidase protein and mRNA are decreased during egg aging down
3.5.1.23 Homo sapiens significantly decreased ceramide levels are observed in human colon cancers, gliomas, ovarian cancers, thyroid and gastrointestinal cancers down

General Information

EC Number General Information Comment Organism
3.5.1.23 malfunction inhibition of acid ceramidase activity stimulates apoptotic cell death. Point mutations in the acid ceramidase gene cause rare autosomal recessive Farber disease. Homozygous acid ceramidase-deficient mice are embryonic lethal Mus musculus
3.5.1.23 physiological function the enzyme determines cell fate, namely, death or survival, by controlling the balance between the intracellular levels of ceramide and sphingosine 1-phosphate. Acid ceramidase plays an important role in tumorigenesis and in prolonging the survival of cells Homo sapiens