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Literature summary extracted from
- Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation (2004), FEBS Lett., 563, 93-97.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.18.5 | expressed in HEK-293 cells | Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.5 | 35000 | - |
x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
| 1.14.18.5 | 41200 | - |
x * 41200, estimated from amino acid sequence | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.5 | Homo sapiens | Q6QHC5 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.5 | intestine | - |
Homo sapiens | - |
| 1.14.18.5 | kidney | - |
Homo sapiens | - |
| 1.14.18.5 | additional information | not detected in heart, liver, spleen, skeletal muscle, thymus or placenta | Homo sapiens | - |
| 1.14.18.5 | skin | highest expression in skin | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.5 | dihydroceramide + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytoceramide + acceptor + H2O | - |
? |  |
| 1.14.18.5 | N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.14.18.5 | sphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytosphingosine + acceptor + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.18.5 | ? | x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
| 1.14.18.5 | ? | x * 41200, estimated from amino acid sequence | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.5 | DES2 | - |
Homo sapiens |
| 1.14.18.5 | dihydroceramide hydroxylase | - |
Homo sapiens |
| 1.14.18.5 | sphingolipid C4-hydroxylase | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.18.5 | Homo sapiens | the enzyme is up-regulated during keratinocyte differentiation | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.18.5 | physiological function | the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues | Homo sapiens |
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Release 2023.1 (January 2023)
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