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Literature summary extracted from

  • Fellermeier, M.; Zenk, M.
    Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol (1998), FEBS Lett., 427, 283-285.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.102 additional information
-
 additional information Michaelis-Menten kinetics with geranyl diphosphate as substrate Cannabis sativa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.102 Mg2+ essentially required Cannabis sativa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.102 geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate Cannabis sativa
-
 diphosphate + cannabigerolate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.102 Cannabis sativa
-
 var. Skunk
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.102 leaf young Cannabis sativa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.102 geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
-
 Cannabis sativa diphosphate + cannabigerolate
-
 ?
2.5.1.102 geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate i.e. olivetolate Cannabis sativa diphosphate + cannabigerolate
-
 ?
2.5.1.102 additional information the enzyme accepts geranyldiphosphate and to a lesser degree also neryldiphosphate as a cosubstrate. Olivetol is inactive as a prenyl acceptor, GOT is specific for olivetolic acid Cannabis sativa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.102 geranylpyrophosphate:olivetolate geranyltransferase
-
 Cannabis sativa
2.5.1.102 GOT
-
 Cannabis sativa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.102 30
-
-
 Cannabis sativa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.102 7
-
-
 Cannabis sativa

General Information

EC Number General Information Comment Organism
2.5.1.102 metabolism GOT is the first enzyme in the biosynthesis of DELTA1-tetrahydrocannabinolic acid and cannabinoids Cannabis sativa