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Literature summary extracted from

  • Gruber, H.E.; Hoelscher, G.L.; Ingram, J.A.; Hanley, E.N.
    Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro (2011), Exp. Mol. Pathol., 92, 59-63.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.B7 medicine slight, but significant, downregulation of MMP-26 in more degenerated intervertebral discs (Thompson grades III, IV and V) compared to healthier discs, while both TGF-beta and latent transforming growth factor-beta binding protein 2 are significantly and strongly upregulated Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B7 activated pro-MMP-9 + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 denatured collagen type I + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 denatured collagen type II + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 denatured collagen type III + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 denatured collagen type IV + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 Fibrinogen + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 Fibronectin + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 insulin-like growth factor binding protein 1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 Type IV collagen + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B7 Vitronectin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B7 Homo sapiens
-
-
-
3.4.24.B7 Homo sapiens Q9NRE1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B7 annulus fibrosus disci intervertebralis
-
 Homo sapiens
-
3.4.24.B7 intervertebral disc in the outer and inner annulus and in the nucleus pulposus Homo sapiens
-
3.4.24.B7 intervertebral disc constitutive expression. Protein is found in both disc cells and in the disc extracellular matrix. MMP-26 is identified in the outer and inner annulus and in the nucleus pulposus. Fewer cells show localization in the inner vs. outer annulus, and localization is sparse in the nucleus Homo sapiens
-
3.4.24.B7 nucleus pulposus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B7 activated pro-MMP-9 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 denatured collagen type I + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 denatured collagen type II + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 denatured collagen type III + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 denatured collagen type IV + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 insulin-like growth factor binding protein 1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 Type IV collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B7 Vitronectin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B7 endometase
-
 Homo sapiens
3.4.24.B7 matrilysin-2
-
 Homo sapiens
3.4.24.B7 MMP-26
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.24.B7 Homo sapiens there is significant downregulation of expression of MMP-26 in more degenerated discs vs. healthier discs down
3.4.24.B7 Homo sapiens significant downregulation of expression of MMP-26, and significant 9.8fold upregulation of TGF-beta in more degenerated discs versus healthier discs down

General Information

EC Number General Information Comment Organism
3.4.24.B7 physiological function MMP-26 plays an important role of in matrix modulation during disc health and degeneration Homo sapiens