Literature summary extracted from

Kantsadi, A.L.; Manta, S.; Psarra, A.M.; Dimopoulou, A.; Kiritsis, C.; Parmenopoulou, V.; Skamnaki, V.T.; Zoumpoulakis, P.; Zographos, S.E.; Leonidas, D.D.; Komiotis, D.
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment (2012), Eur. J. Med. Chem., 54, 740-749.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.4.1.1	AMP	-	Oryctolagus cuniculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.1.1	1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil	-	Oryctolagus cuniculus
2.4.1.1	1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil	-	Oryctolagus cuniculus
2.4.1.1	1-(beta-D-glucopyranosyl)-5-ethynyluracil	cytotoxic effect on Hep-G2 cells	Oryctolagus cuniculus
2.4.1.1	1-(beta-D-glucopyranosyl)-5-iodouracil	-	Oryctolagus cuniculus
2.4.1.1	3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one	-	Oryctolagus cuniculus
2.4.1.1	3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one	-	Oryctolagus cuniculus
2.4.1.1	alpha-D-glucose	physiological inhibitor	Oryctolagus cuniculus
2.4.1.1	additional information	synthesis of glucopyranonucleosides in the 5-alkynyl- and 6-alkylfurano[2,3-d]pyrimidine series, overview	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.1	[(1->4)-alpha-D-glucosyl]n + phosphate	Oryctolagus cuniculus	-	[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.1	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.1.1	muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.1	[(1->4)-alpha-D-glucosyl]n + phosphate	-	Oryctolagus cuniculus	[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.1	glycogen phosphorylase b	-	Oryctolagus cuniculus
2.4.1.1	GPb	-	Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.4.1.1	30	-	assay at	Oryctolagus cuniculus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.4.1.1	6.8	-	assay at	Oryctolagus cuniculus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.4.1.1	0.001	-	1-(beta-D-glucopyranosyl)-5-iodouracil	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	0.0047	-	1-(beta-D-glucopyranosyl)-5-ethynyluracil	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	0.0324	-	3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	0.0334	-	3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	0.303	-	1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	1.7	-	alpha-D-glucose	pH 6.8, 30°C	Oryctolagus cuniculus
2.4.1.1	3.204	-	1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil	pH 6.8, 30°C	Oryctolagus cuniculus

General Information

EC Number	General Information	Comment	Organism
2.4.1.1	additional information	structural analysis of molecular elements that govern molecular recognition by the catalytic site of the enzyme with emphasis in the beta-pocket environment, overview	Oryctolagus cuniculus

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Release 2023.1 (January 2023)