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Literature summary extracted from

  • Wachino, J.; Arakawa, Y.
    Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update (2012), Drug Resist. Updat., 15, 133-148.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Micromonospora zionensis
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Micromonospora echinospora
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Proteus mirabilis
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Micromonospora inyonensis
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Streptoalloteichus hindustanus
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Streptomyces kanamyceticus
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Serratia marcescens
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Pseudomonas aeruginosa
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Citrobacter freundii
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Micromonospora olivasterospora
2.1.1.179 drug development development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria Micromonospora rosea

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.179 gene fmrO, phylogenetic analysis, sequence comparisons Micromonospora olivasterospora
2.1.1.179 gene grmA, phylogenetic analysis, sequence comparisons Micromonospora echinospora
2.1.1.179 gene grmB, phylogenetic analysis, sequence comparisons Micromonospora rosea
2.1.1.179 gene kmr, phylogenetic analysis, sequence comparisons Streptomyces kanamyceticus
2.1.1.179 gene nbrB, phylogenetic analysis, sequence comparisons Streptoalloteichus hindustanus
2.1.1.179 gene rmtA, phylogenetic analysis, sequence comparisons Pseudomonas aeruginosa
2.1.1.179 gene rmtB, phylogenetic analysis, sequence comparisons Serratia marcescens
2.1.1.179 gene rmtC, phylogenetic analysis, sequence comparisons Proteus mirabilis
2.1.1.179 gene rmtD2, phylogenetic analysis, sequence comparisons Citrobacter freundii
2.1.1.179 gene sgm, phylogenetic analysis, sequence comparisons Micromonospora zionensis
2.1.1.179 gene smr1, phylogenetic analysis, sequence comparisons Micromonospora inyonensis
2.1.1.179 phylogenetic analysis, sequence comparisons Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Micromonospora zionensis
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Micromonospora echinospora
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Proteus mirabilis
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Micromonospora inyonensis
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Streptoalloteichus hindustanus
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Streptomyces kanamyceticus
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Serratia marcescens
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Pseudomonas aeruginosa
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Citrobacter freundii
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Micromonospora olivasterospora
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Micromonospora rosea
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Proteus mirabilis ARS68
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.179 Citrobacter freundii E9N3S1 RmtD2; gene rmtD2
-
2.1.1.179 Micromonospora echinospora Q70KC8 GrmA; gene grmA
-
2.1.1.179 Micromonospora inyonensis Q5Y813 Smr1; gene smr1
-
2.1.1.179 Micromonospora olivasterospora Q08325 FmrO; gene fmrO
-
2.1.1.179 Micromonospora rosea P24619 GrmB; gene grmB
-
2.1.1.179 Micromonospora zionensis Q7M0R2 Sgm; gene sgm
-
2.1.1.179 Proteus mirabilis Q33DX5 RmtC; gene rmtC
-
2.1.1.179 Proteus mirabilis ARS68 Q33DX5 RmtC; gene rmtC
-
2.1.1.179 Pseudomonas aeruginosa A0MK31 RmtD; gene rmtD
-
2.1.1.179 Pseudomonas aeruginosa Q8GRA1 RmtA; gene rmtA
-
2.1.1.179 Serratia marcescens Q76G15 RmtB; gene rmtB
-
2.1.1.179 Streptoalloteichus hindustanus O52472 NbrB; gene nbrB
-
2.1.1.179 Streptomyces kanamyceticus Q75PS4 Kmr; gene kmr
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Micromonospora zionensis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Micromonospora echinospora S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Proteus mirabilis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Micromonospora inyonensis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Streptoalloteichus hindustanus S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Streptomyces kanamyceticus S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Serratia marcescens S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Pseudomonas aeruginosa S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Citrobacter freundii S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Micromonospora olivasterospora S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Micromonospora rosea S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.179 16S rRNA methyltransferase
-
 Micromonospora zionensis
2.1.1.179 16S rRNA methyltransferase
-
 Micromonospora echinospora
2.1.1.179 16S rRNA methyltransferase
-
 Proteus mirabilis
2.1.1.179 16S rRNA methyltransferase
-
 Micromonospora inyonensis
2.1.1.179 16S rRNA methyltransferase
-
 Streptoalloteichus hindustanus
2.1.1.179 16S rRNA methyltransferase
-
 Streptomyces kanamyceticus
2.1.1.179 16S rRNA methyltransferase
-
 Serratia marcescens
2.1.1.179 16S rRNA methyltransferase
-
 Pseudomonas aeruginosa
2.1.1.179 16S rRNA methyltransferase
-
 Citrobacter freundii
2.1.1.179 16S rRNA methyltransferase
-
 Micromonospora olivasterospora
2.1.1.179 16S rRNA methyltransferase
-
 Micromonospora rosea
2.1.1.179 16S-RMTase
-
 Micromonospora zionensis
2.1.1.179 16S-RMTase
-
 Micromonospora echinospora
2.1.1.179 16S-RMTase
-
 Proteus mirabilis
2.1.1.179 16S-RMTase
-
 Micromonospora inyonensis
2.1.1.179 16S-RMTase
-
 Streptoalloteichus hindustanus
2.1.1.179 16S-RMTase
-
 Streptomyces kanamyceticus
2.1.1.179 16S-RMTase
-
 Serratia marcescens
2.1.1.179 16S-RMTase
-
 Pseudomonas aeruginosa
2.1.1.179 16S-RMTase
-
 Citrobacter freundii
2.1.1.179 16S-RMTase
-
 Micromonospora olivasterospora
2.1.1.179 16S-RMTase
-
 Micromonospora rosea
2.1.1.179 FmrO
-
 Micromonospora olivasterospora
2.1.1.179 GrmA
-
 Micromonospora echinospora
2.1.1.179 GrmB
-
 Micromonospora rosea
2.1.1.179 Kmr
-
 Streptomyces kanamyceticus
2.1.1.179 N7-G1405 16S-RMTase
-
 Micromonospora zionensis
2.1.1.179 N7-G1405 16S-RMTase
-
 Micromonospora echinospora
2.1.1.179 N7-G1405 16S-RMTase
-
 Proteus mirabilis
2.1.1.179 N7-G1405 16S-RMTase
-
 Micromonospora inyonensis
2.1.1.179 N7-G1405 16S-RMTase
-
 Streptoalloteichus hindustanus
2.1.1.179 N7-G1405 16S-RMTase
-
 Streptomyces kanamyceticus
2.1.1.179 N7-G1405 16S-RMTase
-
 Serratia marcescens
2.1.1.179 N7-G1405 16S-RMTase
-
 Pseudomonas aeruginosa
2.1.1.179 N7-G1405 16S-RMTase
-
 Citrobacter freundii
2.1.1.179 N7-G1405 16S-RMTase
-
 Micromonospora olivasterospora
2.1.1.179 N7-G1405 16S-RMTase
-
 Micromonospora rosea
2.1.1.179 NbrB
-
 Streptoalloteichus hindustanus
2.1.1.179 RmtA
-
 Pseudomonas aeruginosa
2.1.1.179 RmtB
-
 Serratia marcescens
2.1.1.179 RmtC
-
 Proteus mirabilis
2.1.1.179 RmtD
-
 Pseudomonas aeruginosa
2.1.1.179 RmtD2
-
 Citrobacter freundii
2.1.1.179 sgm
-
 Micromonospora zionensis
2.1.1.179 Smr1
-
 Micromonospora inyonensis

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.179 S-adenosyl-L-methionine
-
 Micromonospora zionensis
2.1.1.179 S-adenosyl-L-methionine
-
 Micromonospora echinospora
2.1.1.179 S-adenosyl-L-methionine
-
 Proteus mirabilis
2.1.1.179 S-adenosyl-L-methionine
-
 Micromonospora inyonensis
2.1.1.179 S-adenosyl-L-methionine
-
 Streptoalloteichus hindustanus
2.1.1.179 S-adenosyl-L-methionine
-
 Streptomyces kanamyceticus
2.1.1.179 S-adenosyl-L-methionine
-
 Serratia marcescens
2.1.1.179 S-adenosyl-L-methionine
-
 Pseudomonas aeruginosa
2.1.1.179 S-adenosyl-L-methionine
-
 Citrobacter freundii
2.1.1.179 S-adenosyl-L-methionine
-
 Micromonospora olivasterospora
2.1.1.179 S-adenosyl-L-methionine
-
 Micromonospora rosea

General Information

EC Number General Information Comment Organism
2.1.1.179 evolution FmrO shows intrinsic N7-G1405 16S-RMTase activity Micromonospora olivasterospora
2.1.1.179 evolution RmtA shows aquired N7-G1405 16S-RMTase activity Pseudomonas aeruginosa
2.1.1.179 evolution RmtB shows aquired N7-G1405 16S-RMTase activity Serratia marcescens
2.1.1.179 evolution RmtC shows aquired N7-G1405 16S-RMTase activity Proteus mirabilis
2.1.1.179 evolution RmtD shows aquired N7-G1405 16S-RMTase activity Pseudomonas aeruginosa
2.1.1.179 evolution RmtD2 shows aquired N7-G1405 16S-RMTase activity Citrobacter freundii
2.1.1.179 additional information GrmA shows intrinsic N7-G1405 16S-RMTase activity Micromonospora echinospora
2.1.1.179 additional information GrmB shows intrinsic N7-G1405 16S-RMTase activity Micromonospora rosea
2.1.1.179 additional information Kmr shows intrinsic N7-G1405 16S-RMTase activity Streptomyces kanamyceticus
2.1.1.179 additional information NbrB shows intrinsic N7-G1405 16S-RMTase activity Streptoalloteichus hindustanus
2.1.1.179 additional information Sgm shows intrinsic N7-G1405 16S-RMTase activity Micromonospora zionensis
2.1.1.179 additional information Smr1 shows intrinsic N7-G1405 16S-RMTase activity Micromonospora inyonensis
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis, These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Micromonospora olivasterospora
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Micromonospora zionensis
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Micromonospora echinospora
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Micromonospora inyonensis
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Streptoalloteichus hindustanus
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Streptomyces kanamyceticus
2.1.1.179 physiological function most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Micromonospora rosea
2.1.1.179 physiological function the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Proteus mirabilis
2.1.1.179 physiological function the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Serratia marcescens
2.1.1.179 physiological function the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Citrobacter freundii
2.1.1.179 physiological function the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Pseudomonas aeruginosa clinical isolates show high-level resistance to clinically useful aminoglycosides through the production of acquired 16S-RMTase. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview Pseudomonas aeruginosa