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Literature summary extracted from
- Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana (2009), Drug Discov. Ther., 3, 83-87.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.21.3.7 | expressed using a baculovirus insect expression system and expressed in transgenic Nicotiana tabacum hairy roots and methylotrophic yeast Pichia pastoris | Cannabis sativa |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.3.7 | additional information | the enzyme does not require any metal ions for activity | Cannabis sativa |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.21.3.7 | 76000 | - |
about 76000 Da, gel filtration | Cannabis sativa |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.21.3.7 | Cannabis sativa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.21.3.7 | DE-52 column chromatography, phenyl Sepharose CL-4B column chromatography, and hydroxylapatite column chromatography | Cannabis sativa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.3.7 | cannabigerolate + O2 | maximum conversion rate of about 98% in 24 h | Cannabis sativa | DELTA9-tetrahydrocannabinolate + H2O2 | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.21.3.7 | monomer | 1 * about 75000, SDS-PAGE | Cannabis sativa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.21.3.7 | THCA synthase | - |
Cannabis sativa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.3.7 | FAD | the enzyme contains covalently attached FAD at a molar ratio of FAD to protein of 1:1 | Cannabis sativa | |
| 1.21.3.7 | additional information | the enzyme does not require any cofactors or coenzymes | Cannabis sativa |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.21.3.7 | metabolism | key enzyme in the synthesis of tetrahydrocannabinolate | Cannabis sativa |
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Release 2023.1 (January 2023)
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