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Literature summary extracted from

  • Lewis, R.A.; Nunns, L.; Thirlway, J.; Carroll, K.; Smith, C.P.; Micklefield, J.
    Active site modification of the beta-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides (2011), Chem. Commun. (Camb. ), 47, 1860-1862.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.179 expressed in Escherichia coli BL21(DE3) Streptomyces coelicolor

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.179 F107I less efficient than wild type protein Streptomyces coelicolor
2.3.1.179 F107L less efficient than wild type protein Streptomyces coelicolor
2.3.1.179 F107S suggested that the Ser residue has less significant effects than the Ile and Leu mutations Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.179 Streptomyces coelicolor
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Synonyms

EC Number Synonyms Comment Organism
2.3.1.179 beta-ketoacyl-ACP synthase FabF3 KAS-II homologue Streptomyces coelicolor

General Information

EC Number General Information Comment Organism
2.3.1.179 physiological function encoded in the gene cluster required for biosynthesis of the calcium dependent antibiotics Streptomyces coelicolor