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Literature summary extracted from

  • Cheng, K.; Liu, J.; Sun, H.; Xie, J.
    Synthesis of oleanolic acid dimers as inhibitors of glycogen phosphorylase (2010), Chem. Biodivers., 7, 690-697.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.1 AMP binds at the allosteric site Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.1 (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
 Oryctolagus cuniculus
2.4.1.1 alpha-D-glucose 6-phosphate binds at the allosteric site Oryctolagus cuniculus
2.4.1.1 bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
-
 Oryctolagus cuniculus
2.4.1.1 Caffeine
-
 Oryctolagus cuniculus
2.4.1.1 hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
-
 Oryctolagus cuniculus
2.4.1.1 iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
-
 Oryctolagus cuniculus
2.4.1.1 additional information the purine inhibitory site binds purine derivatives as well as pentacyclic triterpenes. Synthesis and inhibitory potencies of triazole-linked oleanolic acid dimers as enzyme inhibitors, overview. No inhibition by hexane-1,6-diyl(3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate) and dibenzyl (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oate Oryctolagus cuniculus
2.4.1.1 oleanolic acid a naturally existing pentacyclic triterpene Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.1 Mg2+ activates Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.1 [(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
 [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.1 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.1 additional information the catalytic site binds glucose 1-phosphate, glycogen, glucose, and glucose analogues Oryctolagus cuniculus ?
-
 ?
2.4.1.1 [(1->4)-alpha-D-glucosyl]n + phosphate
-
 Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.4.1.1 glycogen phosphorylase a
-
 Oryctolagus cuniculus
2.4.1.1 GPA
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.1 22
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.1 7.2
-
 assay at Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.1 0.00259
-
 pH 7.2, 22°C Oryctolagus cuniculus (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
2.4.1.1 0.00325
-
 pH 7.2, 22°C Oryctolagus cuniculus iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
2.4.1.1 0.0123
-
 pH 7.2, 22°C Oryctolagus cuniculus bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
2.4.1.1 0.0207
-
 pH 7.2, 22°C Oryctolagus cuniculus hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
2.4.1.1 0.1023
-
 pH 7.2, 22°C Oryctolagus cuniculus Caffeine