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Literature summary extracted from

  • Hawinkels, L.J.; Kuiper, P.; Wiercinska, E.; Verspaget, H.W.; Liu, Z.; Pardali, E.; Sier, C.F.; ten Dijke, P.
    Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis (2010), Cancer Res., 70, 4141-4150.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 GM6001 broad-spectrum matrix metalloproteinase inhibitor, strong inhibition Homo sapiens
3.4.24.80 marimastat strong inhibition Homo sapiens
3.4.24.80 additional information not inhibited by E-64 and aprotinin Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.80 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 carcinoma cell
-
 Homo sapiens
-
3.4.24.80 ECRF cell
-
 Homo sapiens
-
3.4.24.80 endothelial cell
-
 Homo sapiens
-
3.4.24.80 HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 endoglin + H2O MMP-14 cleaves membrane-bound endoglin at a site in close proximity to the transmembrane domain between Gly586-Leu-587 Homo sapiens soluble endoglin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 matrix metalloproteinase-14
-
 Homo sapiens
3.4.24.80 membrane-type 1 matrix metalloproteinase
-
 Homo sapiens
3.4.24.80 MMP14
-
 Homo sapiens
3.4.24.80 MT1-MMP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.80 physiological function in endothelial cells, MMP-14 is the main endoglin shedding protease Homo sapiens